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Meropenem and Hepatic necrosis - a phase IV clinical study of FDA data

Summary:

Hepatic necrosis is reported as a side effect among people who take Meropenem (meropenem), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Pantoprazole, and have High blood pressure.

The phase IV clinical study analyzes which people have Hepatic necrosis when taking Meropenem. It is created by eHealthMe based on reports of 33,250 people who have side effects when taking Meropenem from the FDA, and is updated regularly.

What is Meropenem?

Meropenem has active ingredients of meropenem. eHealthMe is studying from 33,295 Meropenem users. Check the latest studies of Meropenem.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 591 drugs and 744 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

33,250 people reported to have side effects when taking Meropenem.
Among them, 62 people (0.19%) have Hepatic necrosis.

Could Meropenem cause Hepatic necrosis?

Among these 62 people:

How long have people been on Meropenem when they have Hepatic necrosis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hepatic necrosis when taking Meropenem? *

  • female: 20.34 %
  • male: 79.66 %

What is the age of people who have Hepatic necrosis when taking Meropenem? *

  • 0-1: 1.69 %
  • 2-9: 1.69 %
  • 10-19: 5.08 %
  • 20-29: 8.47 %
  • 30-39: 6.78 %
  • 40-49: 6.78 %
  • 50-59: 18.64 %
  • 60+: 50.85 %

What are other drugs people take besides Meropenem? *

  1. Pantoprazole: 23 people, 37.10%
  2. Vancomycin: 22 people, 35.48%
  3. Truvada: 22 people, 35.48%
  4. Kaletra: 22 people, 35.48%
  5. Tivicay: 21 people, 33.87%
  6. Piperacillin And Tazobactam: 19 people, 30.65%
  7. Valtrex: 11 people, 17.74%
  8. Heparin: 9 people, 14.52%
  9. Hydrocortisone: 8 people, 12.90%
  10. Ceftriaxone: 7 people, 11.29%

What are other side effects people have besides Hepatic necrosis? *

  1. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 35 people, 56.45%
  2. Bleeding Disorders: 32 people, 51.61%
  3. Fever: 28 people, 45.16%
  4. Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 27 people, 43.55%
  5. Splenomegaly (enlargement of spleen): 26 people, 41.94%
  6. Hepatomegaly (abnormal enlargement of the liver): 26 people, 41.94%
  7. Acute Kidney Failure: 26 people, 41.94%
  8. Hepatotoxicity (chemical-driven liver damage): 25 people, 40.32%
  9. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 25 people, 40.32%
  10. Acidosis (build-up of carbon dioxide in the blood): 24 people, 38.71%

What are the existing conditions these people have? *

  1. Hiv Infection: 23 people, 37.10%
  2. Oesophageal Candidiasis (fungal infection of oesophagus): 23 people, 37.10%
  3. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 23 people, 37.10%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 37.10%
  5. High Blood Pressure: 23 people, 37.10%
  6. Gastritis (inflammation of stomach): 21 people, 33.87%
  7. Enterobacter Infection (infection caused by bacteria of the family enterobacteriaceae): 10 people, 16.13%
  8. Fever: 7 people, 11.29%
  9. Septic Shock (shock due to blood infection): 6 people, 9.68%
  10. Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina): 6 people, 9.68%

* Approximation only. Some reports may have incomplete information.

Do you take Meropenem and have Hepatic necrosis?

- Check whether Hepatic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Meropenem:

Hepatic necrosis treatments and more:

How severe was Hepatic necrosis and when was it recovered:

Expand to all the drugs that have ingredients of meropenem:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Meropenem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic necrosis:

Browse all the conditions that are associated with Hepatic necrosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on meropenem (the active ingredients of Meropenem) and Meropenem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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