Metadate cd and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Metadate cd (methylphenidate hydrochloride), especially for people who are male, 2-9 old, have been taking the drug for < 1 month also take Depakote, and have Autism.

The phase IV clinical study analyzes which people have Agitation when taking Metadate cd. It is created by eHealthMe based on reports of 514 people who have side effects when taking Metadate cd from the FDA, and is updated regularly.

What is Metadate cd?

Metadate cd has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 646 Metadate cd users. Check the latest studies of Metadate cd.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,283 drugs and 3,318 conditions by eHealthMe. Check the latest studies of Agitation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

514 people reported to have side effects when taking Metadate cd.
Among them, 16 people (3.11%) have Agitation.

Among these 16 people:

How long have people been on Metadate cd when they have Agitation? *

What is the gender of people who have Agitation when taking Metadate cd? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Agitation when taking Metadate cd? *

What are other drugs people take besides Metadate cd? *

What are other side effects people have besides Agitation? *

Aggression: 4 people, 25.00%
Weight Decreased: 2 people, 12.50%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 2 people, 12.50%
Skin Blushing/flushing (a sudden reddening of the face, neck): 2 people, 12.50%
Heart Rate Increased: 2 people, 12.50%
Disturbance In Attention: 1 person, 6.25%
Feeling Abnormal: 1 person, 6.25%
Excitability: 1 person, 6.25%
Erection Increased: 1 person, 6.25%
Drowsiness: 1 person, 6.25%

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 6.25%
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Metadate cd and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metadate cd:

Metadate cd (646 reports)

Agitation treatments and more:

Agitation (142,109 reports)

Browse all side effects of Metadate cd:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,283 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,318 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Metadate cd) and Metadate cd (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.