Metaglip and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Metaglip (glipizide; metformin hydrochloride), especially for people who are female, 60+ old, also take Atenolol, and have Thyroid diseases.

The phase IV clinical study analyzes which people have Insomnia when taking Metaglip. It is created by eHealthMe based on reports of 622 people who have side effects when taking Metaglip from the FDA, and is updated regularly.

What is Metaglip?

Metaglip has active ingredients of glipizide; metformin hydrochloride. It is often used in type 2 diabetes. eHealthMe is studying from 629 Metaglip users. Check the latest studies of Metaglip.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,118 drugs and 5,169 conditions by eHealthMe. Check the latest studies of Insomnia.

On Jul, 16, 2026

622 people reported to have side effects when taking Metaglip.
Among them, 11 people (1.77%) have Insomnia.

Among these 11 people:

What is the gender of people who have Insomnia when taking Metaglip? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Insomnia when taking Metaglip? *

What are other drugs people take besides Metaglip? *

What are other side effects people have besides Insomnia? *

Weight Increased: 7 people, 63.64%
Thyroid Diseases: 5 people, 45.45%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 45.45%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Weakness: 3 people, 27.27%
Dizziness: 3 people, 27.27%
Headache (pain in head): 3 people, 27.27%
Chest Pain: 2 people, 18.18%
Fatigue (feeling of tiredness): 2 people, 18.18%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 18.18%

What are the existing conditions these people have? *

Thyroid Diseases: 5 people, 45.45%
Nicotine Dependence: 3 people, 27.27%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 9.09%
Quit Smoking: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Bipolar Disorder (mood disorder): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Metaglip and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metaglip:

Metaglip (629 reports)

Insomnia treatments and more:

Insomnia (438,078 reports)

How severe was Insomnia and when was it recovered:

Insomnia in Metaglip

Expand to all the drugs that have ingredients of glipizide; metformin hydrochloride:

Insomnia and drugs with ingredients of glipizide; metformin hydrochloride (16 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metaglip:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,118 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,169 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glipizide; metformin hydrochloride (the active ingredients of Metaglip) and Metaglip (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.