Methadone hydrochloride and Bradycardia - a phase IV clinical study of FDA data

Summary:

Bradycardia is reported as a side effect among people who take Methadone hydrochloride (methadone hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Diazepam, and have Ventricular arrhythmia.

The phase IV clinical study analyzes which people have Bradycardia when taking Methadone hydrochloride. It is created by eHealthMe based on reports of 6,737 people who have side effects when taking Methadone hydrochloride from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Bradycardia?

Bradycardia (abnormally slow heart action) is found to be associated with 1,930 drugs and 3,118 conditions by eHealthMe. Check the latest studies of Bradycardia.

On Jul, 11, 2026

6,737 people reported to have side effects when taking Methadone hydrochloride.
Among them, 23 people (0.34%) have Bradycardia.

Could Methadone hydrochloride cause Bradycardia?

Among these 23 people:

How long have people been on Methadone hydrochloride when they have Bradycardia? *

What is the gender of people who have Bradycardia when taking Methadone hydrochloride? *

female: 42.86 %
male: 57.14 %

What is the age of people who have Bradycardia when taking Methadone hydrochloride? *

What are other drugs people take besides Methadone hydrochloride? *

What are other side effects people have besides Bradycardia? *

Hypotension (abnormally low blood pressure): 8 people, 34.78%
Electrocardiogram Qt Prolonged: 6 people, 26.09%
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 6 people, 26.09%
Torsade De Pointes (a abnormal heart rate with abnormal beating pattern): 4 people, 17.39%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 3 people, 13.04%
Ventricular Fibrillation (abnormally irregular heart rhythm): 3 people, 13.04%
Consciousness - Decreased: 3 people, 13.04%
Drowsiness: 3 people, 13.04%
Fainting (loss of consciousness and postural tone): 3 people, 13.04%
Blood Creatinine Increased: 2 people, 8.70%

What are the existing conditions these people have? *

Drug Dependence: 2 people, 8.70%
Ventricular Arrhythmia (problem with the rate or rhythm of the heartbeat): 2 people, 8.70%
Weakness: 1 person, 4.35%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 4.35%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 4.35%
Blast Crisis In Myelogenous Leukaemia: 1 person, 4.35%
Cancer Pain: 1 person, 4.35%
Cardiac Failure: 1 person, 4.35%
Chronic Renal Failure (kidney failure): 1 person, 4.35%
Depression: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Methadone hydrochloride and have Bradycardia?

- Check whether Bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methadone hydrochloride:

Methadone hydrochloride (8,598 reports)

Bradycardia treatments and more:

Bradycardia (61,180 reports)

Browse all side effects of Methadone hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bradycardia:

Bradycardia (1,930 drugs)

Browse all the conditions that are associated with Bradycardia:

Bradycardia (3,118 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Schlumbrecht MP, Hehr K, "Cisplatin-induced bradycardia and the importance of the QT interval", Journal of Oncology Pharmacy Practice, 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Oflaz MB, Kucukdurmaz Z, Guven AS, Karapinar H, Kaya A, Sancakdar E, Deveci K, Gul I, Erdem A, Cevit O, Icagasioglu FD, "Bradycardia seen in children with Crimean-Congo hemorrhagic fever", Vector-Borne and Zoonotic Diseases, 2013 Nov .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Schlumbrecht MP, Hehr K, "Cisplatin-induced bradycardia and the importance of the QT interval", Journal of Oncology Pharmacy Practice, 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Oflaz MB, Kucukdurmaz Z, Guven AS, Karapinar H, Kaya A, Sancakdar E, Deveci K, Gul I, Erdem A, Cevit O, Icagasioglu FD, "Bradycardia seen in children with Crimean-Congo hemorrhagic fever", Vector-Borne and Zoonotic Diseases, 2013 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on methadone hydrochloride (the active ingredients of Methadone hydrochloride) and Methadone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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