Methadone hydrochloride and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Methadone hydrochloride (methadone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Oxycontin, and have Hepatitis c.

The phase IV clinical study analyzes which people have Depression when taking Methadone hydrochloride. It is created by eHealthMe based on reports of 6,737 people who have side effects when taking Methadone hydrochloride from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Depression?

Depression is found to be associated with 3,168 drugs and 4,127 conditions by eHealthMe. Check the latest studies of Depression.

On Aug, 05, 2026

6,737 people reported to have side effects when taking Methadone hydrochloride.
Among them, 170 people (2.52%) have Depression.

Could Methadone hydrochloride cause Depression?

Among these 170 people:

How long have people been on Methadone hydrochloride when they have Depression? *

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What is the gender of people who have Depression when taking Methadone hydrochloride? *

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What is the age of people who have Depression when taking Methadone hydrochloride? *

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* Approximation only. Some reports may have incomplete information.

Do you take Methadone hydrochloride and have Depression?

- Check whether Depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methadone hydrochloride:

Methadone hydrochloride (8,598 reports)

Depression treatments and more:

Depression (652,152 reports)

How severe was Depression and when was it recovered:

Depression in Methadone hydrochloride

Expand to all the drugs that have ingredients of methadone hydrochloride:

Depression and drugs with ingredients of methadone hydrochloride (1,815 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methadone hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,168 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,127 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methadone hydrochloride (the active ingredients of Methadone hydrochloride) and Methadone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.