Methadose and Hypertension aggravated - a phase IV clinical study of FDA data

Summary:

Hypertension aggravated is reported as a side effect among people who take Methadose (methadone hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Fragmin, and have Oligodendroglioma.

The phase IV clinical study analyzes which people have Hypertension aggravated when taking Methadose. It is created by eHealthMe based on reports of 4,441 people who have side effects when taking Methadose from the FDA, and is updated regularly.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.

What is Hypertension aggravated?

Hypertension aggravated (high blood pressure) is found to be associated with 2,744 drugs and 845 conditions by eHealthMe. Check the latest studies of Hypertension aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

4,441 people reported to have side effects when taking Methadose.
Among them, 55 people (1.24%) have Hypertension aggravated.

Could Methadose cause Hypertension aggravated?

Among these 55 people:

How long have people been on Methadose when they have Hypertension aggravated? *

What is the gender of people who have Hypertension aggravated when taking Methadose? *

female: 27.91 %
male: 72.09 %

What is the age of people who have Hypertension aggravated when taking Methadose? *

What are other drugs people take besides Methadose? *

What are other side effects people have besides Hypertension aggravated? *

Confusional State: 31 people, 56.36%
Headache (pain in head): 30 people, 54.55%
Weight Decreased: 29 people, 52.73%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 28 people, 50.91%
Weight Increased: 27 people, 49.09%
Hemiparesis (weakness on one side of the body): 27 people, 49.09%
Rectal Haemorrhage (bleeding from anus): 27 people, 49.09%
Incoherent (talking in a confused and unclear way): 27 people, 49.09%
Nosebleed (bleeding from nose): 27 people, 49.09%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 27 people, 49.09%

What are the existing conditions these people have? *

Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 27 people, 49.09%
Brain Cancer Metastatic: 6 people, 10.91%
Breakthrough Pain: 4 people, 7.27%
Drug Dependence: 3 people, 5.45%
Depression: 2 people, 3.64%
Poliomyelitis: 2 people, 3.64%
Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 1.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 1.82%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 1.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 1.82%

* Approximation only. Some reports may have incomplete information.

Do you take Methadose and have Hypertension aggravated?

- Check whether Hypertension aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methadose:

Methadose (5,101 reports)

Browse all side effects of Methadose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertension aggravated:

Hypertension aggravated (2,744 drugs)

Browse all the conditions that are associated with Hypertension aggravated:

Hypertension aggravated (845 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methadone hydrochloride (the active ingredients of Methadose) and Methadose (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.