Methergine and Vaginal bleeding - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding is reported as a side effect among people who take Methergine (methylergonovine maleate), especially for people who are 30-39 old, have been taking the drug for < 1 month also take Ranitidine, and have Genital ulceration.

The phase IV clinical study analyzes which people have Vaginal bleeding when taking Methergine. It is created by eHealthMe based on reports of 957 people who have side effects when taking Methergine from the FDA, and is updated regularly.

What is Methergine?

Methergine has active ingredients of methylergonovine maleate. It is often used in migraine. eHealthMe is studying from 999 Methergine users. Check the latest studies of Methergine.

What is Vaginal bleeding?

Vaginal bleeding is found to be associated with 1,129 drugs and 1,539 conditions by eHealthMe. Check the latest studies of Vaginal bleeding.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

957 people reported to have side effects when taking Methergine.
Among them, 23 people (2.4%) have Vaginal bleeding.

Could Methergine cause Vaginal bleeding?

Among these 23 people:

How long have people been on Methergine when they have Vaginal bleeding? *

What is the age of people who have Vaginal bleeding when taking Methergine? *

What are other drugs people take besides Methergine? *

What are other side effects people have besides Vaginal bleeding? *

Abdominal Pain: 9 people, 39.13%
Nausea (feeling of having an urge to vomit): 8 people, 34.78%
Anaemia (lack of blood): 7 people, 30.43%
Drug Exposure During Pregnancy: 7 people, 30.43%
Nausea And Vomiting: 7 people, 30.43%
Oedema Peripheral (superficial swelling): 4 people, 17.39%
Dehydration (dryness resulting from the removal of water): 4 people, 17.39%
Hypotension (abnormally low blood pressure): 4 people, 17.39%
Hyperhidrosis (abnormally increased sweating): 4 people, 17.39%
Vaginal Discharge: 3 people, 13.04%

What are the existing conditions these people have? *

Hiv Infection: 4 people, 17.39%
Uterine Contractions Abnormal: 4 people, 17.39%
Behcet's Syndrome (involves inflammation of the blood vessels): 4 people, 17.39%
Rubella (an infection of the respiratory system caused by a virus): 4 people, 17.39%
Depression: 4 people, 17.39%
Pain: 4 people, 17.39%
Multiple Allergies (allergy to multiple agents): 4 people, 17.39%
Mouth Ulcers: 4 people, 17.39%
Genital Ulceration (ulcers on sex organ): 4 people, 17.39%
Haemorrhage (bleeding): 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

Do you take Methergine and have Vaginal bleeding?

- Check whether Vaginal bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methergine:

Methergine (999 reports)

Vaginal bleeding treatments and more:

Vaginal bleeding (49,485 reports)

Browse all side effects of Methergine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding:

Vaginal bleeding (1,129 drugs)

Browse all the conditions that are associated with Vaginal bleeding:

Vaginal bleeding (1,539 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylergonovine maleate (the active ingredients of Methergine) and Methergine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.