Methotrexate sodium and Anorectal abscess - a phase IV clinical study of FDA data

Summary:

Anorectal abscess is reported as a side effect among people who take Methotrexate sodium (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Orencia, and have Crohn's disease.

The phase IV clinical study analyzes which people have Anorectal abscess when taking Methotrexate sodium. It is created by eHealthMe based on reports of 96,366 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Anorectal abscess?

Anorectal abscess is found to be associated with 648 drugs and 976 conditions by eHealthMe. Check the latest studies of Anorectal abscess.

On May, 02, 2026

96,366 people reported to have side effects when taking Methotrexate sodium.
Among them, 79 people (0.08%) have Anorectal abscess.

Could Methotrexate sodium cause Anorectal abscess?

Among these 79 people:

How long have people been on Methotrexate sodium when they have Anorectal abscess? *

What is the gender of people who have Anorectal abscess when taking Methotrexate sodium? *

female: 61.02 %
male: 38.98 %

What is the age of people who have Anorectal abscess when taking Methotrexate sodium? *

What are other drugs people take besides Methotrexate sodium? *

What are other side effects people have besides Anorectal abscess? *

Diarrhea: 36 people, 45.57%
Weight Decreased: 29 people, 36.71%
Drug Ineffective: 29 people, 36.71%
Malaise (a feeling of general discomfort or uneasiness): 26 people, 32.91%
Joint Pain: 26 people, 32.91%
Pain: 23 people, 29.11%
Tooth Abscess (pus formation in tooth): 21 people, 26.58%
Rashes (redness): 21 people, 26.58%
Rheumatoid Nodule (a local swelling or tissue lump with rheumatoid disease): 21 people, 26.58%
Kidney Stones: 21 people, 26.58%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 27 people, 34.18%
Tinea Infection (fungal skin infection): 2 people, 2.53%
Skin Disorder (skin disease): 2 people, 2.53%
Arthropathy: 2 people, 2.53%
Asthma: 2 people, 2.53%
Blood Disorder: 2 people, 2.53%
Bone Disorder: 2 people, 2.53%
Diabetes: 2 people, 2.53%
High Blood Cholesterol: 2 people, 2.53%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 2 people, 2.53%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Anorectal abscess?

- Check whether Anorectal abscess is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate sodium:

Methotrexate sodium (97,679 reports)

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anorectal abscess:

Anorectal abscess (648 drugs)

Browse all the conditions that are associated with Anorectal abscess:

Anorectal abscess (976 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.