Methotrexate sodium and Partial seizures - a phase IV clinical study of FDA data

Summary:

Partial seizures is reported as a side effect among people who take Methotrexate sodium (methotrexate sodium), especially for people who are female, 10-19 old, also take Vimpat, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Partial seizures when taking Methotrexate sodium. It is created by eHealthMe based on reports of 96,366 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,680 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Partial seizures?

Partial seizures (seizures which affect only a part of the brain at onset) is found to be associated with 476 drugs and 726 conditions by eHealthMe. Check the latest studies of Partial seizures.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

96,366 people reported to have side effects when taking Methotrexate sodium.
Among them, 19 people (0.02%) have Partial seizures.

Could Methotrexate sodium cause Partial seizures?

Among these 19 people:

What is the gender of people who have Partial seizures when taking Methotrexate sodium? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Partial seizures when taking Methotrexate sodium? *

What are other drugs people take besides Methotrexate sodium? *

Ramipril: 4 people, 21.05%
Cosentyx: 4 people, 21.05%
Vimpat: 4 people, 21.05%
Xarelto: 3 people, 15.79%
Torsemide: 3 people, 15.79%
Metformin Hydrochloride: 3 people, 15.79%
Levothyroxine Sodium: 3 people, 15.79%
Finasteride: 2 people, 10.53%
Humira: 1 person, 5.26%
Carmustine: 1 person, 5.26%

What are other side effects people have besides Partial seizures? *

Speech Impairment (Adult) (inability to speak (adult)): 6 people, 31.58%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 31.58%
Fainting (loss of consciousness and postural tone): 5 people, 26.32%
Speech Disorder: 5 people, 26.32%
Weight Loss: 4 people, 21.05%
Myoglobin Blood Increased (presence of myoglobin in blood increased): 4 people, 21.05%
Ldl/hdl Ratio Decreased: 4 people, 21.05%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 4 people, 21.05%
Vascular Encephalopathy (vascular disorder or disease of the brain): 4 people, 21.05%
Glycosylated Haemoglobin Increased: 4 people, 21.05%

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 47.37%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 26.32%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 10.53%
Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 1 person, 5.26%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.26%
Osteosarcoma (a cancerous (malignant) bone tumour): 1 person, 5.26%
Meningeal Disorder (disease of meninges): 1 person, 5.26%
Gastric Disorder (disease of stomach): 1 person, 5.26%
Fever: 1 person, 5.26%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Partial seizures?

- Check whether Partial seizures is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate sodium:

Methotrexate sodium (97,680 reports)

Partial seizures treatments and more:

Partial seizures (17,458 reports)

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Partial seizures:

Partial seizures (476 drugs)

Browse all the conditions that are associated with Partial seizures:

Partial seizures (726 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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