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Methotrexate sodium and Sinus tachycardia - a phase IV clinical study of FDA data

Summary:

Sinus tachycardia is reported as a side effect among people who take Methotrexate sodium (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Sinus tachycardia when taking Methotrexate sodium. It is created by eHealthMe based on reports of 96,366 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Sinus tachycardia?

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node) is found to be associated with 1,269 drugs and 1,411 conditions by eHealthMe. Check the latest studies of Sinus tachycardia.

On Jul, 30, 2026

96,366 people reported to have side effects when taking Methotrexate sodium.
Among them, 43 people (0.04%) have Sinus tachycardia.

Could Methotrexate sodium cause Sinus tachycardia?

Among these 43 people:

How long have people been on Methotrexate sodium when they have Sinus tachycardia? *

  • < 1 month: 33.33 %
  • 1 - 6 months: 8.33 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 8.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 25.0 %

What is the gender of people who have Sinus tachycardia when taking Methotrexate sodium? *

  • female: 60.47 %
  • male: 39.53 %

What is the age of people who have Sinus tachycardia when taking Methotrexate sodium? *

  • 0-1: 0.0 %
  • 2-9: 5.88 %
  • 10-19: 26.47 %
  • 20-29: 5.88 %
  • 30-39: 5.88 %
  • 40-49: 2.94 %
  • 50-59: 17.65 %
  • 60+: 35.29 %

What are other drugs people take besides Methotrexate sodium? *

  1. Folic Acid: 8 people, 18.60%
  2. Humira: 8 people, 18.60%
  3. Acetaminophen: 6 people, 13.95%
  4. Enalapril Maleate: 5 people, 11.63%
  5. Feldene: 5 people, 11.63%
  6. Atenolol: 5 people, 11.63%
  7. Omeprazole: 5 people, 11.63%
  8. Calcium: 4 people, 9.30%
  9. Bactrim: 3 people, 6.98%
  10. Oncaspar: 3 people, 6.98%

What are other side effects people have besides Sinus tachycardia? *

  1. Hypotension (abnormally low blood pressure): 12 people, 27.91%
  2. Fatigue (feeling of tiredness): 9 people, 20.93%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 20.93%
  4. Nausea (feeling of having an urge to vomit): 8 people, 18.60%
  5. Febrile Neutropenia (fever with reduced white blood cells): 8 people, 18.60%
  6. Dizziness: 8 people, 18.60%
  7. Joint Pain: 6 people, 13.95%
  8. Fainting (loss of consciousness and postural tone): 6 people, 13.95%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 11.63%
  10. Weight Decreased: 5 people, 11.63%

What are the existing conditions these people have? *

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 9.30%
  2. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 6.98%
  3. Anaplastic Large Cell Lymphoma T- And Null-Cell Types (t-cell or null-cell cancer, a type of blood cancer): 3 people, 6.98%
  4. Pain: 3 people, 6.98%
  5. Inflammation: 2 people, 4.65%
  6. High Blood Pressure: 2 people, 4.65%
  7. Latent Tuberculosis (hidden tuberculosis): 2 people, 4.65%
  8. Gynecomastia (enlargement of the gland tissue of the male breast): 2 people, 4.65%
  9. Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 2.33%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Sinus tachycardia?

- Check whether Sinus tachycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate sodium:

Sinus tachycardia treatments and more:

How severe was Sinus tachycardia and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus tachycardia:

Browse all the conditions that are associated with Sinus tachycardia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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