Methotrexate sodium and Sluggishness - a phase IV clinical study of FDA data

Summary:

Sluggishness is reported as a side effect among people who take Methotrexate sodium (methotrexate sodium), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Enbrel, and have Osteoporosis.

The phase IV clinical study analyzes which people have Sluggishness when taking Methotrexate sodium. It is created by eHealthMe based on reports of 96,366 people who have side effects when taking Methotrexate sodium from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,680 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Sluggishness?

Sluggishness (lacking alertness) is found to be associated with 790 drugs and 747 conditions by eHealthMe. Check the latest studies of Sluggishness.

On Aug, 08, 2026

96,366 people reported to have side effects when taking Methotrexate sodium.
Among them, 18 people (0.02%) have Sluggishness.

Could Methotrexate sodium cause Sluggishness?

Among these 18 people:

How long have people been on Methotrexate sodium when they have Sluggishness? *

What is the gender of people who have Sluggishness when taking Methotrexate sodium? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Sluggishness when taking Methotrexate sodium? *

What are other drugs people take besides Methotrexate sodium? *

What are other side effects people have besides Sluggishness? *

Nausea And Vomiting: 6 people, 33.33%
Pain: 5 people, 27.78%
Weakness: 5 people, 27.78%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 27.78%
Fatigue (feeling of tiredness): 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 4 people, 22.22%
Drowsiness: 4 people, 22.22%
Cough: 4 people, 22.22%
Chills (felling of cold): 3 people, 16.67%
Joint Pain: 3 people, 16.67%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 3 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Bone Disorder: 2 people, 11.11%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%
Pain: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 5.56%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate sodium and have Sluggishness?

- Check whether Sluggishness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate sodium:

Methotrexate sodium (97,680 reports)

Sluggishness treatments and more:

Sluggishness (11,737 reports)

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sluggishness:

Sluggishness (790 drugs)

Browse all the conditions that are associated with Sluggishness:

Sluggishness (747 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate sodium) and Methotrexate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.