Methyldopa and Renal impairment - a phase IV clinical study of FDA data

Summary:

Renal impairment is reported as a side effect among people who take Methyldopa (methyldopa), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have Chronic kidney disease.

The phase IV clinical study analyzes which people have Renal impairment when taking Methyldopa. It is created by eHealthMe based on reports of 6,345 people who have side effects when taking Methyldopa from the FDA, and is updated regularly.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

What is Renal impairment?

Renal impairment (severely reduced kidney function) is found to be associated with 2,209 drugs and 2,472 conditions by eHealthMe. Check the latest studies of Renal impairment.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

6,345 people reported to have side effects when taking Methyldopa.
Among them, 88 people (1.39%) have Renal impairment.

Could Methyldopa cause Renal impairment?

Among these 88 people:

How long have people been on Methyldopa when they have Renal impairment? *

What is the gender of people who have Renal impairment when taking Methyldopa? *

female: 70.59 %
male: 29.41 %

What is the age of people who have Renal impairment when taking Methyldopa? *

What are other drugs people take besides Methyldopa? *

What are other side effects people have besides Renal impairment? *

Maternal Exposure During Pregnancy (use of substance during pregnancy): 17 people, 19.32%
Premature Delivery: 14 people, 15.91%
Pleural Effusion (water on the lungs): 11 people, 12.50%
Thrombocytopenia (decrease of platelets in blood): 11 people, 12.50%
Hyperbilirubinaemia (excess of bilirubin in the blood): 9 people, 10.23%
Nausea And Vomiting: 9 people, 10.23%
Anaemia (lack of blood): 9 people, 10.23%
Premature Labor: 8 people, 9.09%
Oedema Peripheral (superficial swelling): 8 people, 9.09%
Pre-Eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman): 8 people, 9.09%

What are the existing conditions these people have? *

Chronic Kidney Disease: 8 people, 9.09%
Gastrointestinal Stromal Tumor: 6 people, 6.82%
Hypervolaemia (abnormally increased volume of blood): 6 people, 6.82%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 4 people, 4.55%
Spinal Muscular Atrophy (wasting of spinal muscles): 4 people, 4.55%
Pain: 4 people, 4.55%
Gestational Hypertension (elevated blood pressure during pregnancy): 3 people, 3.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 3.41%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 3.41%
Immunodeficiency Disorders: 3 people, 3.41%

* Approximation only. Some reports may have incomplete information.

Do you take Methyldopa and have Renal impairment?

- Check whether Renal impairment is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methyldopa:

Methyldopa (6,475 reports)

Renal impairment treatments and more:

Renal impairment (99,633 reports)

Browse all side effects of Methyldopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Renal impairment:

Renal impairment (2,209 drugs)

Browse all the conditions that are associated with Renal impairment:

Renal impairment (2,472 conditions)

Related publications that referenced our studies

Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methyldopa (the active ingredients of Methyldopa) and Methyldopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.