Methylene blue and Hyperreflexia - a phase IV clinical study of FDA data

Summary:

Hyperreflexia is reported as a side effect among people who take Methylene blue (methylene blue), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Midazolam, and have Depression.

The phase IV clinical study analyzes which people have Hyperreflexia when taking Methylene blue. It is created by eHealthMe based on reports of 1,056 people who have side effects when taking Methylene blue from the FDA, and is updated regularly.

What is Methylene blue?

Methylene blue has active ingredients of methylene blue. eHealthMe is studying from 1,064 Methylene blue users. Check the latest studies of Methylene blue.

What is Hyperreflexia?

Hyperreflexia (overactive or over responsive reflexes) is found to be associated with 420 drugs and 651 conditions by eHealthMe. Check the latest studies of Hyperreflexia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

1,056 people reported to have side effects when taking Methylene blue.
Among them, 27 people (2.56%) have Hyperreflexia.

Could Methylene blue cause Hyperreflexia?

Among these 27 people:

How long have people been on Methylene blue when they have Hyperreflexia? *

What is the gender of people who have Hyperreflexia when taking Methylene blue? *

female: 68 %
male: 32 %

What is the age of people who have Hyperreflexia when taking Methylene blue? *

What are other drugs people take besides Methylene blue? *

What are other side effects people have besides Hyperreflexia? *

Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 24 people, 88.89%
Agitation (state of anxiety or nervous excitement): 17 people, 62.96%
Muscle Rigidity (muscle stiffness): 14 people, 51.85%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 13 people, 48.15%
Mydriasis (a dilation of the pupil): 12 people, 44.44%
Confusional State: 11 people, 40.74%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 9 people, 33.33%
Fever: 9 people, 33.33%
Blood Creatinine Increased: 8 people, 29.63%
Hyperpyrexia (extremely high fever): 8 people, 29.63%

What are the existing conditions these people have? *

Depression: 17 people, 62.96%
Anaesthesia: 8 people, 29.63%
General Anaesthesia: 7 people, 25.93%
Pain: 5 people, 18.52%
Hypotonia (low muscle tone): 4 people, 14.81%
Vasoplegia Syndrome (low systemic vascular resistance): 3 people, 11.11%
Affective Disorder (mental disorder): 3 people, 11.11%
Nausea And Vomiting: 3 people, 11.11%
Hypotension (abnormally low blood pressure): 3 people, 11.11%
Encephalopathy (functioning of the brain is affected by some agent or condition): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Methylene blue and have Hyperreflexia?

- Check whether Hyperreflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylene blue:

Methylene blue (1,064 reports)

Hyperreflexia treatments and more:

Hyperreflexia (4,677 reports)

Browse all side effects of Methylene blue:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperreflexia:

Hyperreflexia (420 drugs)

Browse all the conditions that are associated with Hyperreflexia:

Hyperreflexia (651 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylene blue (the active ingredients of Methylene blue) and Methylene blue (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.