Methylfolate and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Methylfolate (folic acid), especially for people who are female, 30-39 old, also take Prilosec, and have Pain.

The phase IV clinical study analyzes which people have Insomnia when taking Methylfolate. It is created by eHealthMe based on reports of 820 people who have side effects when taking Methylfolate from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,016 Methylfolate users. Check the latest studies of Methylfolate.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,119 drugs and 5,158 conditions by eHealthMe. Check the latest studies of Insomnia.

On Apr, 12, 2026

820 people reported to have side effects when taking Methylfolate.
Among them, 46 people (5.61%) have Insomnia.

Among these 46 people:

What is the gender of people who have Insomnia when taking Methylfolate? *

female: 76.09 %
male: 23.91 %

What is the age of people who have Insomnia when taking Methylfolate? *

What are other drugs people take besides Methylfolate? *

What are other side effects people have besides Insomnia? *

Weakness: 14 people, 30.43%
Headache (pain in head): 12 people, 26.09%
Diarrhea: 11 people, 23.91%
Cough: 11 people, 23.91%
Constipation: 11 people, 23.91%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 11 people, 23.91%
Iron Deficiency: 10 people, 21.74%
High Blood Pressure: 10 people, 21.74%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 9 people, 19.57%
Granulocytosis (the presence in peripheral blood of an increased number of granulocytes): 9 people, 19.57%

What are the existing conditions these people have? *

Pain: 17 people, 36.96%
High Blood Pressure: 14 people, 30.43%
Sedation: 12 people, 26.09%
High Blood Cholesterol: 12 people, 26.09%
Agitation (state of anxiety or nervous excitement): 12 people, 26.09%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 11 people, 23.91%
Depression: 11 people, 23.91%
Nausea (feeling of having an urge to vomit): 10 people, 21.74%
Wheezing (a high-pitched whistling sound made while you breath): 9 people, 19.57%
Nasal Discomfort: 9 people, 19.57%

* Approximation only. Some reports may have incomplete information.

Do you take Methylfolate and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylfolate:

Methylfolate (1,016 reports)

Insomnia treatments and more:

Insomnia (438,061 reports)

Browse all side effects of Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,119 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,158 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Methylfolate) and Methylfolate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.