Methylfolate and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Methylfolate (folic acid), especially for people who are female, 60+ old, also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint swelling when taking Methylfolate. It is created by eHealthMe based on reports of 820 people who have side effects when taking Methylfolate from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Joint swelling?

Joint swelling is found to be associated with 2,122 drugs and 2,935 conditions by eHealthMe. Check the latest studies of Joint swelling.

On Jul, 18, 2026

820 people reported to have side effects when taking Methylfolate.
Among them, 11 people (1.34%) have Joint swelling.

Could Methylfolate cause Joint swelling?

Among these 11 people:

What is the gender of people who have Joint swelling when taking Methylfolate? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Joint swelling when taking Methylfolate? *

What are other drugs people take besides Methylfolate? *

What are other side effects people have besides Joint swelling? *

Joint Pain: 6 people, 54.55%
Peripheral Swelling: 4 people, 36.36%
Speech Impairment (Adult) (inability to speak (adult)): 3 people, 27.27%
Confusional State: 3 people, 27.27%
Mobility Decreased (ability to move is reduced): 3 people, 27.27%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 27.27%
The Flu (the flu is caused by an influenza virus): 3 people, 27.27%
Oedema Peripheral (superficial swelling): 3 people, 27.27%
Pain: 3 people, 27.27%
Oedema (fluid collection in tissue): 2 people, 18.18%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 45.45%
Stress And Anxiety: 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%
Chest Pain: 2 people, 18.18%
Diarrhea: 2 people, 18.18%
Hypophosphatasia (metabolic bone disease): 2 people, 18.18%
Sleep Disorder: 2 people, 18.18%
Muscle Aches (muscle pain): 2 people, 18.18%
Pain: 2 people, 18.18%
Pain In Extremity: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Methylfolate and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylfolate:

Methylfolate (1,018 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,122 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,935 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Methylfolate) and Methylfolate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.