Methylphenidate and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Methylphenidate (methylphenidate), especially for people who are female, 10-19 old, also take Vitamin B12, and have Joint pain.

The phase IV clinical study analyzes which people have Joint stiffness when taking Methylphenidate. It is created by eHealthMe based on reports of 8,120 people who have side effects when taking Methylphenidate from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,299 drugs and 1,338 conditions by eHealthMe. Check the latest studies of Joint stiffness.

On Jun, 09, 2026

8,120 people reported to have side effects when taking Methylphenidate.
Among them, 12 people (0.15%) have Joint stiffness.

Could Methylphenidate cause Joint stiffness?

Among these 12 people:

What is the gender of people who have Joint stiffness when taking Methylphenidate? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Joint stiffness when taking Methylphenidate? *

What are other drugs people take besides Methylphenidate? *

Vitamin B12: 4 people, 33.33%
Zopiclone: 3 people, 25.00%
Oracort: 3 people, 25.00%
Voltaren: 3 people, 25.00%
Naproxen: 3 people, 25.00%
Cosentyx: 3 people, 25.00%
Omega 3: 3 people, 25.00%
Rosuvastatin Calcium: 2 people, 16.67%
Metformin Hydrochloride: 2 people, 16.67%
Esomeprazole Magnesium: 2 people, 16.67%

What are other side effects people have besides Joint stiffness? *

Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 5 people, 41.67%
Muscle Contracture (a permanent shortening of a muscle): 5 people, 41.67%
Affect Lability (emotional incontinence): 5 people, 41.67%
Aggression: 5 people, 41.67%
Intentional Self-Injury: 5 people, 41.67%
Trismus (reduced opening of the jaws): 5 people, 41.67%
Movement - Uncontrolled Or Slow: 5 people, 41.67%
Joint Pain: 4 people, 33.33%
Neck Pain: 3 people, 25.00%
Itching: 3 people, 25.00%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 25.00%
Joint Pain: 3 people, 25.00%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 8.33%
Dyspnea (difficult or laboured breathing): 1 person, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 8.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 8.33%
Constipation: 1 person, 8.33%
Depression: 1 person, 8.33%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate:

Methylphenidate (8,216 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,299 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,338 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate (the active ingredients of Methylphenidate) and Methylphenidate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.