Methylphenidate and Lactic acidosis - a phase IV clinical study of FDA data

Summary:

Lactic acidosis is reported as a side effect among people who take Methylphenidate (methylphenidate), especially for people who are male, 10-19 old, have been taking the drug for 1 - 2 years also take Celecoxib, and have Attention deficit hyperactivity disorder.

The phase IV clinical study analyzes which people have Lactic acidosis when taking Methylphenidate. It is created by eHealthMe based on reports of 8,120 people who have side effects when taking Methylphenidate from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Lactic acidosis?

Lactic acidosis (low ph in body tissues) is found to be associated with 995 drugs and 1,276 conditions by eHealthMe. Check the latest studies of Lactic acidosis.

On Jul, 17, 2026

8,120 people reported to have side effects when taking Methylphenidate.
Among them, 14 people (0.17%) have Lactic acidosis.

Could Methylphenidate cause Lactic acidosis?

Among these 14 people:

How long have people been on Methylphenidate when they have Lactic acidosis? *

What is the gender of people who have Lactic acidosis when taking Methylphenidate? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Lactic acidosis when taking Methylphenidate? *

What are other drugs people take besides Methylphenidate? *

What are other side effects people have besides Lactic acidosis? *

Overdose: 8 people, 57.14%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 5 people, 35.71%
Skull Fracture: 1 person, 7.14%
Renal Cyst (kidney cyst): 1 person, 7.14%
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased): 1 person, 7.14%
Loss Of Consciousness: 1 person, 7.14%
Kidney Stones: 1 person, 7.14%
Fall: 1 person, 7.14%
Fainting (loss of consciousness and postural tone): 1 person, 7.14%
Dehydration (dryness resulting from the removal of water): 1 person, 7.14%

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 7.14%
Drowsiness: 1 person, 7.14%
Diarrhea: 1 person, 7.14%
Blood Bicarbonate Decreased: 1 person, 7.14%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and have Lactic acidosis?

- Check whether Lactic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate:

Methylphenidate (8,216 reports)

Lactic acidosis treatments and more:

Lactic acidosis (34,314 reports)

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lactic acidosis:

Lactic acidosis (995 drugs)

Browse all the conditions that are associated with Lactic acidosis:

Lactic acidosis (1,276 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate (the active ingredients of Methylphenidate) and Methylphenidate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.