Methylprednisolone and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Methylprednisolone (methylprednisolone), especially for people who are female, 2-9 old, have been taking the drug for < 1 month also take Mycophenolate Mofetil, and have Graft versus host disease in skin.

The study is created by eHealthMe based on reports of 58,374 people who have side effects when taking Methylprednisolone from the FDA, and is updated regularly.

What is Methylprednisolone?

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

58,374 people reported to have side effects when taking Methylprednisolone.
Among them, 25 people (0.04%) died.

Could Methylprednisolone cause Brain death?

Among these 25 people:

How long have people been on Methylprednisolone when they died? *

What is the gender of people who died when taking Methylprednisolone? *

female: 54.17 %
male: 45.83 %

What is the age of people who died when taking Methylprednisolone? *

What are other drugs people take besides Methylprednisolone? *

Mycophenolate Mofetil: 10 people, 40.00%
Cyclosporine: 8 people, 32.00%
Methotrexate: 6 people, 24.00%
Cyclophosphamide: 6 people, 24.00%
Busulfan: 6 people, 24.00%
Prednisolone: 5 people, 20.00%
Tacrolimus: 5 people, 20.00%
Bactrim: 3 people, 12.00%
Fentanyl: 3 people, 12.00%
Acetaminophen: 3 people, 12.00%

What are other side effects people have before they died? *

Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 8 people, 32.00%
Haemorrhage Intracranial (bleeding within the skull): 7 people, 28.00%
Bleeding Disorders: 7 people, 28.00%
Microangiopathic Haemolytic Anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells): 6 people, 24.00%
Nausea (feeling of having an urge to vomit): 4 people, 16.00%
Nausea And Vomiting: 4 people, 16.00%
Pleural Effusion (water on the lungs): 4 people, 16.00%
Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 4 people, 16.00%
Weakness: 3 people, 12.00%
Respiratory Distress (difficulty in breathing): 3 people, 12.00%

What are the existing conditions these people have? *

Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 6 people, 24.00%
Bone Marrow Conditioning Regimen: 5 people, 20.00%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 8.00%
Venous Occlusion (the blocking of venous return): 2 people, 8.00%
Myelitis Transverse (a neurological condition consisting of an inflammatory process of the spinal cord): 1 person, 4.00%
Liver Disorder (liver diseases): 1 person, 4.00%
Irritable Bowel Syndrome: 1 person, 4.00%
Immunodeficiency Disorders: 1 person, 4.00%
Type 1 Diabetes: 1 person, 4.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylprednisolone:

Methylprednisolone (59,645 reports)

Expand to all the drugs that have ingredients of methylprednisolone:

Brain death and drugs with ingredients of methylprednisolone

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylprednisolone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (315 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methylprednisolone (the active ingredients of Methylprednisolone) and Methylprednisolone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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