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Methylprednisolone and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Methylprednisolone (methylprednisolone), especially for people who are female, 60+ old, also take Tacrolimus, and have Chronic graft versus host disease.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Methylprednisolone. It is created by eHealthMe based on reports of 58,374 people who have side effects when taking Methylprednisolone from the FDA, and is updated regularly.

What is Methylprednisolone?

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 495 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jul, 11, 2026

58,374 people reported to have side effects when taking Methylprednisolone.
Among them, 57 people (0.1%) have Systemic sclerosis (scleroderma).

Could Methylprednisolone cause Systemic sclerosis (scleroderma)?

Among these 57 people:

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Methylprednisolone? *

  • female: 56.25 %
  • male: 43.75 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Methylprednisolone? *

  • 0-1: 0.0 %
  • 2-9: 10.34 %
  • 10-19: 3.45 %
  • 20-29: 17.24 %
  • 30-39: 10.34 %
  • 40-49: 13.79 %
  • 50-59: 13.79 %
  • 60+: 31.03 %

What are other drugs people take besides Methylprednisolone? *

  1. Tacrolimus: 29 people, 50.88%
  2. Mycophenolate Mofetil: 27 people, 47.37%
  3. Cyclosporine: 25 people, 43.86%
  4. Methotrexate: 22 people, 38.60%
  5. Prednisone: 18 people, 31.58%
  6. Sirolimus: 14 people, 24.56%
  7. Acetaminophen: 9 people, 15.79%
  8. Prednisolone: 9 people, 15.79%
  9. Diphenhydramine Hydrochloride: 6 people, 10.53%
  10. Cyclophosphamide: 5 people, 8.77%

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

  1. Disease Progression: 16 people, 28.07%
  2. Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 15 people, 26.32%
  3. Drug Ineffective: 11 people, 19.30%
  4. Thrombocytopenia (decrease of platelets in blood): 10 people, 17.54%
  5. Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 7 people, 12.28%
  6. Nausea And Vomiting: 6 people, 10.53%
  7. High Blood Pressure: 6 people, 10.53%
  8. Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 6 people, 10.53%
  9. Pain: 6 people, 10.53%
  10. Blood Pressure Fluctuation: 5 people, 8.77%

What are the existing conditions these people have? *

  1. Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 17 people, 29.82%
  2. Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 6 people, 10.53%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 8.77%
  4. Interstitial Lung Disease: 4 people, 7.02%
  5. Anaemia Haemolytic Autoimmune (a condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells): 4 people, 7.02%
  6. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 3 people, 5.26%
  7. Pulmonary Hypertension Secondary (increase in blood pressure in the lung artery): 2 people, 3.51%
  8. Insomnia (sleeplessness): 2 people, 3.51%
  9. Pyoderma (any skin disease that is pyogenic): 2 people, 3.51%
  10. Bone Marrow Conditioning Regimen: 2 people, 3.51%

* Approximation only. Some reports may have incomplete information.

Do you take Methylprednisolone and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylprednisolone:

Systemic sclerosis (scleroderma) treatments and more:

How severe was Systemic sclerosis (scleroderma) and when was it recovered:

Expand to all the drugs that have ingredients of methylprednisolone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylprednisolone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

How the study uses the data?

The study uses data from the FDA. It is based on methylprednisolone (the active ingredients of Methylprednisolone) and Methylprednisolone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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