Metoclopramide and Hyperreflexia - a phase IV clinical study of FDA data

Summary:

Hyperreflexia is reported as a side effect among people who take Metoclopramide (metoclopramide hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Ondansetron, and have Depression.

The phase IV clinical study analyzes which people have Hyperreflexia when taking Metoclopramide. It is created by eHealthMe based on reports of 80,804 people who have side effects when taking Metoclopramide from the FDA, and is updated regularly.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.

What is Hyperreflexia?

Hyperreflexia (overactive or over responsive reflexes) is found to be associated with 430 drugs and 649 conditions by eHealthMe. Check the latest studies of Hyperreflexia.

On Jul, 04, 2026

80,804 people reported to have side effects when taking Metoclopramide.
Among them, 99 people (0.12%) have Hyperreflexia.

Could Metoclopramide cause Hyperreflexia?

Among these 99 people:

How long have people been on Metoclopramide when they have Hyperreflexia? *

What is the gender of people who have Hyperreflexia when taking Metoclopramide? *

female: 63.04 %
male: 36.96 %

What is the age of people who have Hyperreflexia when taking Metoclopramide? *

What are other drugs people take besides Metoclopramide? *

What are other side effects people have besides Hyperreflexia? *

Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 50 people, 50.51%
Agitation (state of anxiety or nervous excitement): 43 people, 43.43%
Arrhythmias (irregular heartbeat): 36 people, 36.36%
Hyperhidrosis (abnormally increased sweating): 30 people, 30.30%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 29 people, 29.29%
Tremor (trembling or shaking movements in one or more parts of your body): 28 people, 28.28%
Fever: 27 people, 27.27%
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 23 people, 23.23%
Stress And Anxiety: 21 people, 21.21%
High Blood Pressure: 20 people, 20.20%

What are the existing conditions these people have? *

Depression: 13 people, 13.13%
Hyperemesis Gravidarum (a condition characterized by severe nausea, vomiting, weight loss, and electrolyte disturbance): 12 people, 12.12%
Pain: 11 people, 11.11%
Migraine (headache): 10 people, 10.10%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 9 people, 9.09%
Morning Sickness (sickness in morning during pregnancy): 8 people, 8.08%
Fever: 8 people, 8.08%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 8 people, 8.08%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 8 people, 8.08%
Body Temperature Increased: 7 people, 7.07%

* Approximation only. Some reports may have incomplete information.

Do you take Metoclopramide and have Hyperreflexia?

- Check whether Hyperreflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metoclopramide:

Metoclopramide (81,263 reports)

Hyperreflexia treatments and more:

Hyperreflexia (4,677 reports)

Browse all side effects of Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperreflexia:

Hyperreflexia (430 drugs)

Browse all the conditions that are associated with Hyperreflexia:

Hyperreflexia (649 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Metoclopramide) and Metoclopramide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.