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Metoclopramide and Muscle spasticity - a phase IV clinical study of FDA data

Summary:

Muscle spasticity is reported as a side effect among people who take Metoclopramide (metoclopramide hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Ondansetron, and have Migraine.

The phase IV clinical study analyzes which people have Muscle spasticity when taking Metoclopramide. It is created by eHealthMe based on reports of 80,804 people who have side effects when taking Metoclopramide from the FDA, and is updated regularly.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.

What is Muscle spasticity?

Muscle spasticity (tight or stiff muscles and an inability to control those muscles) is found to be associated with 722 drugs and 667 conditions by eHealthMe. Check the latest studies of Muscle spasticity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

80,804 people reported to have side effects when taking Metoclopramide.
Among them, 48 people (0.06%) have Muscle spasticity.

Could Metoclopramide cause Muscle spasticity?

Among these 48 people:

How long have people been on Metoclopramide when they have Muscle spasticity? *

  • < 1 month: 69.23 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 7.69 %
  • 2 - 5 years: 15.38 %
  • 5 - 10 years: 7.69 %
  • 10+ years: 0.0 %

What is the gender of people who have Muscle spasticity when taking Metoclopramide? *

  • female: 82.22 %
  • male: 17.78 %

What is the age of people who have Muscle spasticity when taking Metoclopramide? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.94 %
  • 20-29: 5.88 %
  • 30-39: 20.59 %
  • 40-49: 47.06 %
  • 50-59: 14.71 %
  • 60+: 8.82 %

What are other drugs people take besides Metoclopramide? *

  1. Ondansetron: 16 people, 33.33%
  2. Sumatriptan: 9 people, 18.75%
  3. Lorazepam: 9 people, 18.75%
  4. Lioresal: 8 people, 16.67%
  5. Prochlorperazine: 8 people, 16.67%
  6. Sodium Bicarbonate: 8 people, 16.67%
  7. Dimenhydrinate: 8 people, 16.67%
  8. Famotidine: 8 people, 16.67%
  9. Pyridoxine: 7 people, 14.58%
  10. Sumatriptan Succinate: 7 people, 14.58%

What are other side effects people have besides Muscle spasticity? *

  1. Tremor (trembling or shaking movements in one or more parts of your body): 16 people, 33.33%
  2. Hyperreflexia (overactive or over responsive reflexes): 16 people, 33.33%
  3. Muscle Aches (muscle pain): 14 people, 29.17%
  4. Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 14 people, 29.17%
  5. Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 13 people, 27.08%
  6. Emotional Distress: 13 people, 27.08%
  7. Headache (pain in head): 12 people, 25.00%
  8. Muscle Spasms (muscle contraction): 11 people, 22.92%
  9. Fever: 10 people, 20.83%
  10. Weakness: 9 people, 18.75%

What are the existing conditions these people have? *

  1. Migraine (headache): 10 people, 20.83%
  2. Morning Sickness (sickness in morning during pregnancy): 8 people, 16.67%
  3. Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 8 people, 16.67%
  4. Hyperemesis Gravidarum (a condition characterized by severe nausea, vomiting, weight loss, and electrolyte disturbance): 8 people, 16.67%
  5. Fever: 8 people, 16.67%
  6. Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 8 people, 16.67%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 14.58%
  8. Body Temperature Increased: 7 people, 14.58%
  9. Birth Control: 6 people, 12.50%
  10. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

Do you take Metoclopramide and have Muscle spasticity?

- Check whether Muscle spasticity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metoclopramide:

Muscle spasticity treatments and more:

How severe was Muscle spasticity and when was it recovered:

Expand to all the drugs that have ingredients of metoclopramide hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle spasticity:

Browse all the conditions that are associated with Muscle spasticity:

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Metoclopramide) and Metoclopramide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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