Metolazone and Aortic valve incompetence - a phase IV clinical study of FDA data

Summary:

Aortic valve incompetence is reported as a side effect among people who take Metolazone (metolazone), especially for people who are male, 60+ old, also take Furosemide, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Aortic valve incompetence when taking Metolazone. It is created by eHealthMe based on reports of 13,337 people who have side effects when taking Metolazone from the FDA, and is updated regularly.

What is Metolazone?

Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 13,411 Metolazone users. Check the latest studies of Metolazone.

What is Aortic valve incompetence?

Aortic valve incompetence is found to be associated with 918 drugs and 881 conditions by eHealthMe. Check the latest studies of Aortic valve incompetence.

On Jul, 16, 2026

13,337 people reported to have side effects when taking Metolazone.
Among them, 29 people (0.22%) have Aortic valve incompetence.

Could Metolazone cause Aortic valve incompetence?

Among these 29 people:

What is the gender of people who have Aortic valve incompetence when taking Metolazone? *

female: 24.14 %
male: 75.86 %

What is the age of people who have Aortic valve incompetence when taking Metolazone? *

What are other drugs people take besides Metolazone? *

What are other side effects people have besides Aortic valve incompetence? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 20 people, 68.97%
Cardiac Failure Congestive: 19 people, 65.52%
Mitral Valve Incompetence (inefficient heart valve): 17 people, 58.62%
Stress And Anxiety: 16 people, 55.17%
Dyspnea (difficult or laboured breathing): 14 people, 48.28%
Anaemia (lack of blood): 14 people, 48.28%
Pain: 14 people, 48.28%
Tricuspid Valve Incompetence (inefficient heart valve): 14 people, 48.28%
Fall: 14 people, 48.28%
Fatigue (feeling of tiredness): 13 people, 44.83%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 20.69%
Depression: 3 people, 10.34%
Cardiac Failure Congestive: 3 people, 10.34%
Acute Kidney Failure: 3 people, 10.34%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 6.90%
Pain: 2 people, 6.90%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.90%
Weight Increased: 1 person, 3.45%
Transfusion Reaction (a serious problem that occurs after a patient receives a transfusion of blood): 1 person, 3.45%
Heart Rate Increased: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Metolazone and have Aortic valve incompetence?

- Check whether Aortic valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metolazone:

Metolazone (13,411 reports)

Browse all side effects of Metolazone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve incompetence:

Aortic valve incompetence (918 drugs)

Browse all the conditions that are associated with Aortic valve incompetence:

Aortic valve incompetence (881 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metolazone (the active ingredients of Metolazone) and Metolazone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.