Metoprolol succinate and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Metoprolol succinate (metoprolol succinate), especially for people who are male, 60+ old, also take Vitamin D3, and have Hyperkalemia.

The study is created by eHealthMe based on reports of 64,247 people who have side effects when taking Metoprolol succinate from the FDA, and is updated regularly.

What is Metoprolol succinate?

Metoprolol succinate has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 66,933 Metoprolol succinate users. Check the latest studies of Metoprolol succinate.

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On Aug, 27, 2026

64,247 people reported to have side effects when taking Metoprolol succinate.
Among them, 11 people (0.02%) died.

Could Metoprolol succinate cause Brain death?

Among these 11 people:

What is the gender of people who died when taking Metoprolol succinate? *

female: 30 %
male: 70 %

What is the age of people who died when taking Metoprolol succinate? *

What are other drugs people take besides Metoprolol succinate? *

What are other side effects people have before they died? *

Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 3 people, 27.27%
Heart Attack: 2 people, 18.18%
Unresponsive To Stimuli: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 18.18%
Cerebral Haemorrhage (bleeding within the brain): 2 people, 18.18%
Loss Of Consciousness: 2 people, 18.18%
Pneumonia: 2 people, 18.18%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 18.18%

What are the existing conditions these people have? *

Hyperkalemia (damage to or disease of the kidney): 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 9.09%
Neck Pain: 1 person, 9.09%
Muscle Spasms (muscle contraction): 1 person, 9.09%
Metastases To Liver (cancer spreads to liver): 1 person, 9.09%
Joint Pain: 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
Hypersensitivity: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metoprolol succinate:

Metoprolol succinate (66,933 reports)

Expand to all the drugs that have ingredients of metoprolol succinate:

Brain death and drugs with ingredients of metoprolol succinate (80 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metoprolol succinate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (315 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Metoprolol succinate) and Metoprolol succinate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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