Microzide and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Microzide (hydrochlorothiazide), especially for people who are female, 40-49 old, also take Vicodin Es, and have Muscle spasms.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Microzide. It is created by eHealthMe based on reports of 946 people who have side effects when taking Microzide from the FDA, and is updated regularly.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,310 drugs and 1,500 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 23, 2026

946 people reported to have side effects when taking Microzide.
Among them, 14 people (1.48%) have Intervertebral disc degeneration.

Could Microzide cause Intervertebral disc degeneration?

Among these 14 people:

What is the gender of people who have Intervertebral disc degeneration when taking Microzide? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Intervertebral disc degeneration when taking Microzide? *

What are other drugs people take besides Microzide? *

What are other side effects people have besides Intervertebral disc degeneration? *

Drug Ineffective: 13 people, 92.86%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 11 people, 78.57%
Fall: 11 people, 78.57%
Ankylosing Spondylitis (type of arthritis affecting the spine): 11 people, 78.57%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 10 people, 71.43%
Constipation: 10 people, 71.43%
Dysphoria (generalized dissatisfaction with life): 10 people, 71.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 71.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 71.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 71.43%

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 11 people, 78.57%
Back Pain: 10 people, 71.43%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 14.29%
Chest Pain: 2 people, 14.29%
Constipation: 2 people, 14.29%
Endocarditis Bacterial (an inflammation of the inner layer of the heart by bacterial infection): 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Insomnia (sleeplessness): 2 people, 14.29%
Nausea (feeling of having an urge to vomit): 2 people, 14.29%
Nausea And Vomiting: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Microzide and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Microzide:

Microzide (994 reports)

Browse all side effects of Microzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,310 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,500 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Microzide) and Microzide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.