Milk thistle and Gastroesophageal reflux disease - a phase IV clinical study of FDA data

Summary:

Gastroesophageal reflux disease is reported as a side effect among people who take Milk thistle (milk thistle), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Fish Oil, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Gastroesophageal reflux disease when taking Milk thistle. It is created by eHealthMe based on reports of 4,531 people who have side effects when taking Milk thistle from the FDA, and is updated regularly.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

What is Gastroesophageal reflux disease?

Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus) is found to be associated with 2,397 drugs and 3,492 conditions by eHealthMe. Check the latest studies of Gastroesophageal reflux disease.

On Jul, 18, 2026

4,531 people reported to have side effects when taking Milk thistle.
Among them, 59 people (1.3%) have Gastroesophageal reflux disease.

Could Milk thistle cause Gastroesophageal reflux disease?

Among these 59 people:

How long have people been on Milk thistle when they have Gastroesophageal reflux disease? *

What is the gender of people who have Gastroesophageal reflux disease when taking Milk thistle? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Gastroesophageal reflux disease when taking Milk thistle? *

What are other drugs people take besides Milk thistle? *

What are other side effects people have besides Gastroesophageal reflux disease? *

Dizziness: 13 people, 22.03%
Stress And Anxiety: 12 people, 20.34%
Diarrhea: 12 people, 20.34%
Nausea (feeling of having an urge to vomit): 11 people, 18.64%
Fatigue (feeling of tiredness): 10 people, 16.95%
High Blood Pressure: 9 people, 15.25%
Rashes (redness): 9 people, 15.25%
Chronic Kidney Disease: 9 people, 15.25%
Acute Kidney Failure: 8 people, 13.56%
Insomnia (sleeplessness): 8 people, 13.56%

What are the existing conditions these people have? *

High Blood Cholesterol: 13 people, 22.03%
High Blood Pressure: 12 people, 20.34%
Pain: 10 people, 16.95%
Stress And Anxiety: 8 people, 13.56%
Constipation: 7 people, 11.86%
Depression: 7 people, 11.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 11.86%
Bipolar Disorder (mood disorder): 6 people, 10.17%
Type 2 Diabetes: 5 people, 8.47%
Affective Disorder (mental disorder): 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

Do you take Milk thistle and have Gastroesophageal reflux disease?

- Check whether Gastroesophageal reflux disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Milk thistle:

Milk thistle (5,057 reports)

Browse all side effects of Milk thistle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastroesophageal reflux disease:

Gastroesophageal reflux disease (2,397 drugs)

Browse all the conditions that are associated with Gastroesophageal reflux disease:

Gastroesophageal reflux disease (3,492 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Milk thistle) and Milk thistle (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.