Minivelle and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Minivelle (estradiol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cymbalta, and have Hot flush.

The phase IV clinical study analyzes which people have Joint swelling when taking Minivelle. It is created by eHealthMe based on reports of 3,457 people who have side effects when taking Minivelle from the FDA, and is updated regularly.

What is Minivelle?

Minivelle has active ingredients of estradiol. eHealthMe is studying from 3,480 Minivelle users. Check the latest studies of Minivelle.

What is Joint swelling?

Joint swelling is found to be associated with 2,120 drugs and 2,934 conditions by eHealthMe. Check the latest studies of Joint swelling.

On Jul, 15, 2026

3,457 people reported to have side effects when taking Minivelle.
Among them, 15 people (0.43%) have Joint swelling.

Among these 15 people:

How long have people been on Minivelle when they have Joint swelling? *

What is the gender of people who have Joint swelling when taking Minivelle? *

female: 100 %
male: 0.0 %

What is the age of people who have Joint swelling when taking Minivelle? *

What are other drugs people take besides Minivelle? *

What are other side effects people have besides Joint swelling? *

Rash Macular (small, flat red spots): 4 people, 26.67%
Headache (pain in head): 4 people, 26.67%
High Blood Pressure: 4 people, 26.67%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%
Oedema Peripheral (superficial swelling): 4 people, 26.67%
Pain In Extremity: 4 people, 26.67%
Oropharyngeal Discomfort (pain or irritation of oropharynx): 3 people, 20.00%
Injection Site Erythema (redness at injection site): 3 people, 20.00%
Joint Pain: 3 people, 20.00%
Dizziness: 3 people, 20.00%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 4 people, 26.67%
Pain: 3 people, 20.00%
Birth Control: 3 people, 20.00%
Bladder Disorder: 3 people, 20.00%
Bladder Spasm: 3 people, 20.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 20.00%
Vitamin B12 Deficiency: 2 people, 13.33%
Atrophic Vulvovaginitis (inflammation of the vulva): 2 people, 13.33%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 13.33%
Menopausal Symptoms: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Minivelle and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Minivelle:

Minivelle (3,480 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Minivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,120 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,934 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Minivelle) and Minivelle (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.