Miralax and Drug-induced liver injury - a phase IV clinical study of FDA data

Summary:

Drug-induced liver injury is reported as a side effect among people who take Miralax (polyethylene glycol 3350), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Colace, and have High blood pressure.

The phase IV clinical study analyzes which people have Drug-induced liver injury when taking Miralax. It is created by eHealthMe based on reports of 80,819 people who have side effects when taking Miralax from the FDA, and is updated regularly.

What is Miralax?

Miralax has active ingredients of polyethylene glycol 3350. It is often used in constipation. eHealthMe is studying from 81,754 Miralax users. Check the latest studies of Miralax.

What is Drug-induced liver injury?

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications) is found to be associated with 1,067 drugs and 1,119 conditions by eHealthMe. Check the latest studies of Drug-induced liver injury.

On Jul, 15, 2026

80,819 people reported to have side effects when taking Miralax.
Among them, 32 people (0.04%) have Drug-induced liver injury.

Could Miralax cause Drug-induced liver injury?

Among these 32 people:

How long have people been on Miralax when they have Drug-induced liver injury? *

What is the gender of people who have Drug-induced liver injury when taking Miralax? *

female: 67.74 %
male: 32.26 %

What is the age of people who have Drug-induced liver injury when taking Miralax? *

What are other drugs people take besides Miralax? *

What are other side effects people have besides Drug-induced liver injury? *

Aspartate Aminotransferase Increased: 8 people, 25.00%
Alanine Aminotransferase Increased: 8 people, 25.00%
Confusional State: 7 people, 21.88%
Fatigue (feeling of tiredness): 7 people, 21.88%
Fever: 6 people, 18.75%
Thrombocytopenia (decrease of platelets in blood): 4 people, 12.50%
Metabolic Encephalopathy (disorder or disease of the brain due to the body's disability to use energy): 4 people, 12.50%
Swallowing Difficulty: 3 people, 9.38%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 9.38%
Rashes (redness): 3 people, 9.38%

What are the existing conditions these people have? *

High Blood Pressure: 9 people, 28.12%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 7 people, 21.88%
Pain: 7 people, 21.88%
Insomnia (sleeplessness): 6 people, 18.75%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 6 people, 18.75%
Nausea (feeling of having an urge to vomit): 5 people, 15.62%
Fever: 5 people, 15.62%
Itching: 4 people, 12.50%
Depression: 4 people, 12.50%
Cellulitis (infection under the skin): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Miralax and have Drug-induced liver injury?

- Check whether Drug-induced liver injury is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Miralax:

Miralax (81,754 reports)

Browse all side effects of Miralax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug-induced liver injury:

Drug-induced liver injury (1,067 drugs)

Browse all the conditions that are associated with Drug-induced liver injury:

Drug-induced liver injury (1,119 conditions)

Related publications that referenced our studies

Zhu XW, Li SJ, "In silico Prediction of Drug-induced Liver Injury Based on Adverse Drug Reaction Reports", Toxicological Sciences, 2017 May .
Zhu XW, Li SJ, "In silico Prediction of Drug-induced Liver Injury Based on Adverse Drug Reaction Reports", Toxicological Sciences, 2017 May .

How the study uses the data?

The study uses data from the FDA. It is based on polyethylene glycol 3350 (the active ingredients of Miralax) and Miralax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.