Mirena and Blister - a phase IV clinical study of FDA data

Summary:

Blister is reported as a side effect among people who take Mirena (levonorgestrel), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Restasis, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Blister when taking Mirena. It is created by eHealthMe based on reports of 143,466 people who have side effects when taking Mirena from the FDA, and is updated regularly.

What is Mirena?

Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.

What is Blister?

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure) is found to be associated with 1,870 drugs and 2,177 conditions by eHealthMe. Check the latest studies of Blister.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

143,466 people reported to have side effects when taking Mirena.
Among them, 59 people (0.04%) have Blister.

Among these 59 people:

How long have people been on Mirena when they have Blister? *

What is the gender of people who have Blister when taking Mirena? *

female: 98.21 %
male: 1.79 %

What is the age of people who have Blister when taking Mirena? *

What are other drugs people take besides Mirena? *

What are other side effects people have besides Blister? *

Pain: 23 people, 38.98%
Rashes (redness): 17 people, 28.81%
Weight Increased: 16 people, 27.12%
Joint Pain: 14 people, 23.73%
Nausea And Vomiting: 13 people, 22.03%
Rhinorrhea (watery mucus discharge from the nose): 12 people, 20.34%
Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone): 11 people, 18.64%
Hot Flush (sudden feelings of heat): 11 people, 18.64%
Fatigue (feeling of tiredness): 11 people, 18.64%
Hypotension (abnormally low blood pressure): 11 people, 18.64%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 22.03%
Stress And Anxiety: 12 people, 20.34%
Psoriasis (immune-mediated disease that affects the skin): 11 people, 18.64%
High Blood Pressure: 10 people, 16.95%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 10 people, 16.95%
Dry Mouth: 10 people, 16.95%
Gastric Ulcer (stomach ulcer): 10 people, 16.95%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.78%
Dry Eyes (lack of adequate tears): 3 people, 5.08%
Migraine (headache): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

Do you take Mirena and have Blister?

- Check whether Blister is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mirena:

Mirena (145,266 reports)

Blister treatments and more:

Blister (62,634 reports)

Browse all side effects of Mirena:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blister:

Blister (1,870 drugs)

Browse all the conditions that are associated with Blister:

Blister (2,177 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Mirena) and Mirena (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.