Mitoxantrone and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Mitoxantrone (mitoxantrone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Etoposide, and have Acute myeloid leukaemia.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Mitoxantrone. It is created by eHealthMe based on reports of 8,117 people who have side effects when taking Mitoxantrone from the FDA, and is updated regularly.

What is Mitoxantrone?

Mitoxantrone has active ingredients of mitoxantrone hydrochloride. eHealthMe is studying from 8,125 Mitoxantrone users. Check the latest studies of Mitoxantrone.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 645 drugs and 807 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

8,117 people reported to have side effects when taking Mitoxantrone.
Among them, 19 people (0.23%) have Hypernatraemia.

Could Mitoxantrone cause Hypernatraemia?

Among these 19 people:

How long have people been on Mitoxantrone when they have Hypernatraemia? *

What is the gender of people who have Hypernatraemia when taking Mitoxantrone? *

female: 15.79 %
male: 84.21 %

What is the age of people who have Hypernatraemia when taking Mitoxantrone? *

What are other drugs people take besides Mitoxantrone? *

What are other side effects people have besides Hypernatraemia? *

Hypotension (abnormally low blood pressure): 8 people, 42.11%
Diarrhea: 6 people, 31.58%
Febrile Neutropenia (fever with reduced white blood cells): 6 people, 31.58%
Encephalopathy (functioning of the brain is affected by some agent or condition): 5 people, 26.32%
Mucosal Inflammation (infection of mucous membrane): 5 people, 26.32%
Renal Tubular Necrosis (death of kidney tubules): 5 people, 26.32%
Arrhythmias (irregular heartbeat): 5 people, 26.32%
Blood Creatinine Increased: 5 people, 26.32%
Nausea And Vomiting: 5 people, 26.32%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 5 people, 26.32%

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 14 people, 73.68%
Acute Leukaemia (blood cancer): 3 people, 15.79%
Pain: 3 people, 15.79%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 15.79%
Cellulitis Staphylococcal (a type of bacteria originated skin soft tissue infection): 3 people, 15.79%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 15.79%
Staphylococcal Sepsis (blood infection by an infection with staphylococcus bacteria): 3 people, 15.79%
Sedation: 2 people, 10.53%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 10.53%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Mitoxantrone and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Mitoxantrone:

Mitoxantrone (8,125 reports)

Hypernatraemia treatments and more:

Hypernatraemia (6,339 reports)

Browse all side effects of Mitoxantrone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Hypernatraemia (645 drugs)

Browse all the conditions that are associated with Hypernatraemia:

Hypernatraemia (807 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on mitoxantrone hydrochloride (the active ingredients of Mitoxantrone) and Mitoxantrone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.