Modafinil and Drug dependence - a phase IV clinical study of FDA data

Summary:

Drug dependence is reported as a side effect among people who take Modafinil (modafinil), especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years also take Xyrem, and have Pain.

The phase IV clinical study analyzes which people have Drug dependence when taking Modafinil. It is created by eHealthMe based on reports of 19,891 people who have side effects when taking Modafinil from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Drug dependence?

Drug dependence is found to be associated with 1,252 drugs and 1,139 conditions by eHealthMe. Check the latest studies of Drug dependence.

On Jul, 18, 2026

19,891 people reported to have side effects when taking Modafinil.
Among them, 82 people (0.41%) have Drug dependence.

Among these 82 people:

How long have people been on Modafinil when they have Drug dependence? *

What is the gender of people who have Drug dependence when taking Modafinil? *

female: 50.7 %
male: 49.3 %

What is the age of people who have Drug dependence when taking Modafinil? *

What are other drugs people take besides Modafinil? *

What are other side effects people have besides Drug dependence? *

Fatigue (feeling of tiredness): 29 people, 35.37%
Depression: 25 people, 30.49%
Stress And Anxiety: 24 people, 29.27%
Headache (pain in head): 19 people, 23.17%
Suicidal Ideation: 19 people, 23.17%
Bipolar Disorder (mood disorder): 14 people, 17.07%
Overdose: 12 people, 14.63%
Tremor (trembling or shaking movements in one or more parts of your body): 11 people, 13.41%
Back Pain: 10 people, 12.20%
Dehydration (dryness resulting from the removal of water): 10 people, 12.20%

What are the existing conditions these people have? *

Pain: 18 people, 21.95%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 18.29%
Back Pain: 9 people, 10.98%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 7.32%
Musculoskeletal Discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 3 people, 3.66%
Hyperhidrosis (abnormally increased sweating): 3 people, 3.66%
Insomnia (sleeplessness): 2 people, 2.44%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 2.44%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 2.44%
Bipolar Disorder (mood disorder): 2 people, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and have Drug dependence?

- Check whether Drug dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Modafinil:

Modafinil (20,805 reports)

Drug dependence treatments and more:

Drug dependence (203,373 reports)

Browse all side effects of Modafinil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug dependence:

Drug dependence (1,252 drugs)

Browse all the conditions that are associated with Drug dependence:

Drug dependence (1,139 conditions)

Related publications that referenced our studies

Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Modafinil) and Modafinil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.