Modafinil and Metamorphopsia - a phase IV clinical study of FDA data

Summary:

Metamorphopsia is reported as a side effect among people who take Modafinil (modafinil), especially for people who are female, 30-39 old, also take Escitalopram, and have Fatigue.

The phase IV clinical study analyzes which people have Metamorphopsia when taking Modafinil. It is created by eHealthMe based on reports of 19,891 people who have side effects when taking Modafinil from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Metamorphopsia?

Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank) is found to be associated with 209 drugs and 368 conditions by eHealthMe. Check the latest studies of Metamorphopsia.

On Aug, 04, 2026

19,891 people reported to have side effects when taking Modafinil.
Among them, 18 people (0.09%) have Metamorphopsia.

Among these 18 people:

What is the gender of people who have Metamorphopsia when taking Modafinil? *

female: 100 %
male: 0.0 %

What is the age of people who have Metamorphopsia when taking Modafinil? *

What are other drugs people take besides Modafinil? *

Escitalopram: 16 people, 88.89%
Baclofen: 9 people, 50.00%
Lioresal: 8 people, 44.44%
Gilenya: 3 people, 16.67%
Escitalopram Oxalate: 1 person, 5.56%

What are other side effects people have besides Metamorphopsia? *

Central Nervous System Lesion (an abnormality in tissue of brain or spinal cord): 17 people, 94.44%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 17 people, 94.44%
Unresponsive To Stimuli: 17 people, 94.44%
Tonic Clonic Movements (generalized seizure that affects the entire brain): 17 people, 94.44%
Dysmetropsia (visual illusions involving an alteration in the size or separation of visual objects): 17 people, 94.44%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 17 people, 94.44%
Headache (pain in head): 17 people, 94.44%
Hemianopia Homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes): 17 people, 94.44%
Irritability: 17 people, 94.44%
Loss Of Consciousness: 17 people, 94.44%

What are the existing conditions these people have? *

Stress And Anxiety: 17 people, 94.44%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 17 people, 94.44%
Fatigue (feeling of tiredness): 17 people, 94.44%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 8 people, 44.44%
Anaemia (lack of blood): 7 people, 38.89%

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and have Metamorphopsia?

- Check whether Metamorphopsia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Modafinil:

Modafinil (20,805 reports)

Metamorphopsia treatments and more:

Metamorphopsia (2,072 reports)

Browse all side effects of Modafinil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metamorphopsia:

Metamorphopsia (209 drugs)

Browse all the conditions that are associated with Metamorphopsia:

Metamorphopsia (368 conditions)

Related publications that referenced our studies

Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Modafinil) and Modafinil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.