Moduretic 5-50 and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Moduretic 5-50 (amiloride hydrochloride; hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Anhydrous Caffeine, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Insomnia when taking Moduretic 5-50. It is created by eHealthMe based on reports of 3,193 people who have side effects when taking Moduretic 5-50 from the FDA, and is updated regularly.

What is Moduretic 5-50?

Moduretic 5-50 has active ingredients of amiloride hydrochloride; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 3,224 Moduretic 5-50 users. Check the latest studies of Moduretic 5-50.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,115 drugs and 5,174 conditions by eHealthMe. Check the latest studies of Insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

3,193 people reported to have side effects when taking Moduretic 5-50.
Among them, 54 people (1.69%) have Insomnia.

Among these 54 people:

How long have people been on Moduretic 5-50 when they have Insomnia? *

What is the gender of people who have Insomnia when taking Moduretic 5-50? *

female: 85.19 %
male: 14.81 %

What is the age of people who have Insomnia when taking Moduretic 5-50? *

What are other drugs people take besides Moduretic 5-50? *

What are other side effects people have besides Insomnia? *

Malaise (a feeling of general discomfort or uneasiness): 22 people, 40.74%
Pain: 22 people, 40.74%
Dizziness: 22 people, 40.74%
Drug Ineffective: 21 people, 38.89%
Fatigue (feeling of tiredness): 21 people, 38.89%
Dyspnea (difficult or laboured breathing): 21 people, 38.89%
Joint Pain: 20 people, 37.04%
Weakness: 20 people, 37.04%
Depression: 20 people, 37.04%
Headache (pain in head): 18 people, 33.33%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 18 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 22.22%
Pain: 11 people, 20.37%
Sleep Disorder: 10 people, 18.52%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 9 people, 16.67%
Headache (pain in head): 9 people, 16.67%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 9 people, 16.67%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 9 people, 16.67%
Head Injury: 8 people, 14.81%
Muscle Aches (muscle pain): 8 people, 14.81%

* Approximation only. Some reports may have incomplete information.

Do you take Moduretic 5-50 and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Moduretic 5-50:

Moduretic 5-50 (3,224 reports)

Insomnia treatments and more:

Insomnia (438,087 reports)

How severe was Insomnia and when was it recovered:

Insomnia in Moduretic 5-50

Expand to all the drugs that have ingredients of amiloride hydrochloride; hydrochlorothiazide:

Insomnia and drugs with ingredients of amiloride hydrochloride; hydrochlorothiazide (71 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Moduretic 5-50:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,115 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,174 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amiloride hydrochloride; hydrochlorothiazide (the active ingredients of Moduretic 5-50) and Moduretic 5-50 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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