Motrin and Drug tolerance increased - a phase IV clinical study of FDA data

Summary:

Drug tolerance increased is reported as a side effect among people who take Motrin (ibuprofen), especially for people who are male, 60+ old, also take Percocet, and have Gout.

The phase IV clinical study analyzes which people have Drug tolerance increased when taking Motrin. It is created by eHealthMe based on reports of 37,107 people who have side effects when taking Motrin from the FDA, and is updated regularly.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

What is Drug tolerance increased?

Drug tolerance increased is found to be associated with 151 drugs and 222 conditions by eHealthMe. Check the latest studies of Drug tolerance increased.

On Jul, 06, 2026

37,107 people reported to have side effects when taking Motrin.
Among them, 11 people (0.03%) have Drug tolerance increased.

Could Motrin cause Drug tolerance increased?

Among these 11 people:

What is the gender of people who have Drug tolerance increased when taking Motrin? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Drug tolerance increased when taking Motrin? *

What are other drugs people take besides Motrin? *

What are other side effects people have besides Drug tolerance increased? *

Pain In Extremity: 6 people, 54.55%
Joint Pain: 6 people, 54.55%
Back Pain: 6 people, 54.55%
Depression: 5 people, 45.45%
Drug Dependence: 5 people, 45.45%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 36.36%
Memory Loss: 4 people, 36.36%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 36.36%
Disturbance In Attention: 4 people, 36.36%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 4 people, 36.36%

What are the existing conditions these people have? *

Back Pain: 3 people, 27.27%
Breakthrough Pain: 3 people, 27.27%
Gout (uric acid crystals building up in the body): 3 people, 27.27%
Thyroid Diseases: 2 people, 18.18%
Quit Smoking: 2 people, 18.18%
Asthma: 2 people, 18.18%
Oxygen Saturation Decreased: 2 people, 18.18%
Cluster Headache (one-sided head pain with tearing): 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Motrin and have Drug tolerance increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Motrin:

Motrin (38,332 reports)

Browse all side effects of Motrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug tolerance increased:

Drug tolerance increased (151 drugs)

Browse all the conditions that are associated with Drug tolerance increased:

Drug tolerance increased (222 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Motrin) and Motrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.