Motrin and Injection site extravasation - a phase IV clinical study of FDA data

Summary:

Injection site extravasation is reported as a side effect among people who take Motrin (ibuprofen), especially for people who are female, 40-49 old, also take Lidocaine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Injection site extravasation when taking Motrin. It is created by eHealthMe based on reports of 37,107 people who have side effects when taking Motrin from the FDA, and is updated regularly.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

What is Injection site extravasation?

Injection site extravasation (flow of (blood or lymph) from injection site) is found to be associated with 553 drugs and 730 conditions by eHealthMe. Check the latest studies of Injection site extravasation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

37,107 people reported to have side effects when taking Motrin.
Among them, 20 people (0.05%) have Injection site extravasation.

Could Motrin cause Injection site extravasation?

Among these 20 people:

What is the gender of people who have Injection site extravasation when taking Motrin? *

female: 80 %
male: 20 %

What is the age of people who have Injection site extravasation when taking Motrin? *

What are other drugs people take besides Motrin? *

What are other side effects people have besides Injection site extravasation? *

Injection Site Pain: 9 people, 45.00%
Fatigue (feeling of tiredness): 6 people, 30.00%
Paraesthesia Oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 5 people, 25.00%
X-Ray Abnormal: 4 people, 20.00%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 4 people, 20.00%
Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 4 people, 20.00%
Chest X-Ray Abnormal: 4 people, 20.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 20.00%
Oral Pain: 4 people, 20.00%
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 4 people, 20.00%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 25.00%
Prostate Cancer: 4 people, 20.00%
Metastases To Bone (cancer spreads to bone): 4 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
Type 2 Diabetes: 2 people, 10.00%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Hypersensitivity: 1 person, 5.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.00%
Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Motrin and have Injection site extravasation?

- Check whether Injection site extravasation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Motrin:

Motrin (38,332 reports)

Browse all side effects of Motrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site extravasation:

Injection site extravasation (553 drugs)

Browse all the conditions that are associated with Injection site extravasation:

Injection site extravasation (730 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Motrin) and Motrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.