Motrin and Joint lock - a phase IV clinical study of FDA data

Summary:

Joint lock is reported as a side effect among people who take Motrin (ibuprofen), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint lock when taking Motrin. It is created by eHealthMe based on reports of 37,107 people who have side effects when taking Motrin from the FDA, and is updated regularly.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

What is Joint lock?

Joint lock is found to be associated with 299 drugs and 493 conditions by eHealthMe. Check the latest studies of Joint lock.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

37,107 people reported to have side effects when taking Motrin.
Among them, 12 people (0.03%) have Joint lock.

Among these 12 people:

What is the gender of people who have Joint lock when taking Motrin? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Joint lock when taking Motrin? *

What are other drugs people take besides Motrin? *

What are other side effects people have besides Joint lock? *

Joint Pain: 6 people, 50.00%
Muscle Spasms (muscle contraction): 4 people, 33.33%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 25.00%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 25.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 3 people, 25.00%
Angioedema (rapid swelling of the dermis): 2 people, 16.67%
Eye Disorder: 2 people, 16.67%
Venous Stasis (a condition of slow blood flow in the veins): 2 people, 16.67%
Injury: 2 people, 16.67%
Head Injury: 2 people, 16.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 33.33%
Thyroid Diseases: 3 people, 25.00%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
Back Pain: 2 people, 16.67%
Breakthrough Pain: 2 people, 16.67%
Cluster Headache (one-sided head pain with tearing): 2 people, 16.67%
Gout (uric acid crystals building up in the body): 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Joint Pain: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Motrin and have Joint lock?

- Check whether Joint lock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Motrin:

Motrin (38,332 reports)

Joint lock treatments and more:

Joint lock (3,416 reports)

Browse all side effects of Motrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint lock:

Joint lock (299 drugs)

Browse all the conditions that are associated with Joint lock:

Joint lock (493 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Motrin) and Motrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.