Multivitamin and Application site discomfort - a phase IV clinical study of FDA data

Summary:

Application site discomfort is reported as a side effect among people who take Multivitamin (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Zecuity, and have Migraine.

The phase IV clinical study analyzes which people have Application site discomfort when taking Multivitamin. It is created by eHealthMe based on reports of 79,185 people who have side effects when taking Multivitamin from the FDA, and is updated regularly.

What is Multivitamin?

Multivitamin has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 83,597 Multivitamin users. Check the latest studies of Multivitamin.

What is Application site discomfort?

Application site discomfort is found to be associated with 91 drugs and 255 conditions by eHealthMe. Check the latest studies of Application site discomfort.

On Jul, 16, 2026

79,185 people reported to have side effects when taking Multivitamin.
Among them, 13 people (0.02%) have Application site discomfort.

Could Multivitamin cause Application site discomfort?

Among these 13 people:

What is the gender of people who have Application site discomfort when taking Multivitamin? *

female: 84.62 %
male: 15.38 %

What is the age of people who have Application site discomfort when taking Multivitamin? *

What are other drugs people take besides Multivitamin? *

What are other side effects people have besides Application site discomfort? *

Application Site Erythema (redness of the skin at application site): 9 people, 69.23%
Application Site Pain: 9 people, 69.23%
Rashes (redness): 5 people, 38.46%
Application Site Burn: 5 people, 38.46%
Application Site Pruritus (application site severe itching of the skin): 4 people, 30.77%
Application Site Discoloration: 4 people, 30.77%
Application Site Warmth: 4 people, 30.77%
Application Site Rash: 4 people, 30.77%
Application Site Vesicles (small bubble within a cell at application site): 3 people, 23.08%
Application Site Swelling: 3 people, 23.08%

What are the existing conditions these people have? *

Migraine (headache): 4 people, 30.77%
High Blood Cholesterol: 2 people, 15.38%
Precancerous Skin Lesion: 2 people, 15.38%
Insomnia (sleeplessness): 2 people, 15.38%
Vaginal Infection: 1 person, 7.69%
Blood Pressure Abnormal: 1 person, 7.69%
Blood Testosterone Decreased: 1 person, 7.69%
Demyelinating Polyneuropathy (disorder that affects the nerves outside of the brain and spinal cord (peripheral nerves)): 1 person, 7.69%
Depression: 1 person, 7.69%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Multivitamin and have Application site discomfort?

- Check whether Application site discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Multivitamin:

Multivitamin (83,597 reports)

Application site discomfort treatments and more:

Application site discomfort (1,767 reports)

How severe was Application site discomfort and when was it recovered:

Application site discomfort in Multivitamin

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Application site discomfort and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (39 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Multivitamin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site discomfort:

Application site discomfort (92 drugs)

Browse all the conditions that are associated with Application site discomfort:

Application site discomfort (255 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Multivitamin) and Multivitamin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.