Myfembree and Hot flush - a phase IV clinical study of FDA data

Summary:

Hot flush is reported as a side effect among people who take Myfembree (estradiol; norethindrone acetate; relugolix), especially for people who are 30-39 old, have been taking the drug for < 1 month also take Ergocalciferol, and have Uterine leiomyoma.

The phase IV clinical study analyzes which people have Hot flush when taking Myfembree. It is created by eHealthMe based on reports of 1,203 people who have side effects when taking Myfembree from the FDA, and is updated regularly.

What is Myfembree?

Myfembree has active ingredients of estradiol; norethindrone acetate; relugolix. eHealthMe is studying from 1,204 Myfembree users. Check the latest studies of Myfembree.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 1,770 drugs and 2,347 conditions by eHealthMe. Check the latest studies of Hot flush.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

1,203 people reported to have side effects when taking Myfembree.
Among them, 50 people (4.16%) have Hot flush.

Among these 50 people:

How long have people been on Myfembree when they have Hot flush? *

What is the age of people who have Hot flush when taking Myfembree? *

What are other drugs people take besides Myfembree? *

What are other side effects people have besides Hot flush? *

Hair Loss: 9 people, 18.00%
Mood Swings (an extreme or rapid change in mood): 7 people, 14.00%
Vaginal Bleeding Between Periods: 6 people, 12.00%
Hyperhidrosis (abnormally increased sweating): 6 people, 12.00%
Depression: 4 people, 8.00%
Night Sweats (sweating in night): 4 people, 8.00%
Weight Increased: 3 people, 6.00%
Dysmenorrhea (painful menstruation): 3 people, 6.00%
Stress And Anxiety: 3 people, 6.00%
Headache (pain in head): 3 people, 6.00%

What are the existing conditions these people have? *

Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 24 people, 48.00%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 11 people, 22.00%
Migraine (headache): 3 people, 6.00%
Iron Deficiency Anaemia: 2 people, 4.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 4.00%
Pain: 2 people, 4.00%
Vaginal Bleeding: 1 person, 2.00%
Bipolar Disorder (mood disorder): 1 person, 2.00%
Fever: 1 person, 2.00%
Indigestion: 1 person, 2.00%

* Approximation only. Some reports may have incomplete information.

Do you take Myfembree and have Hot flush?

- Check whether Hot flush is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Myfembree:

Myfembree (1,204 reports)

Hot flush treatments and more:

Hot flush (91,208 reports)

How severe was Hot flush and when was it recovered:

Hot flush in Myfembree

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate; relugolix:

Hot flush and drugs with ingredients of estradiol; norethindrone acetate; relugolix

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Myfembree:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flush:

Hot flush (1,770 drugs)

Browse all the conditions that are associated with Hot flush:

Hot flush (2,347 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate; relugolix (the active ingredients of Myfembree) and Myfembree (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.