Naprelan and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Naprelan (naproxen sodium), especially for people who are female, 40-49 old, also take Zantac, and have Arthritis.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Naprelan. It is created by eHealthMe based on reports of 687 people who have side effects when taking Naprelan from the FDA, and is updated regularly.

What is Naprelan?

Naprelan has active ingredients of naproxen sodium. eHealthMe is studying from 731 Naprelan users. Check the latest studies of Naprelan.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,310 drugs and 1,500 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

687 people reported to have side effects when taking Naprelan.
Among them, 14 people (2.04%) have Intervertebral disc degeneration.

Could Naprelan cause Intervertebral disc degeneration?

Among these 14 people:

What is the gender of people who have Intervertebral disc degeneration when taking Naprelan? *

female: 92.86 %
male: 7.14 %

What is the age of people who have Intervertebral disc degeneration when taking Naprelan? *

What are other drugs people take besides Naprelan? *

Colace: 9 people, 64.29%
Zantac: 9 people, 64.29%
Compazine: 8 people, 57.14%
Vicoprofen: 8 people, 57.14%
Dexamethasone: 8 people, 57.14%
Restoril: 8 people, 57.14%
Pepcid: 8 people, 57.14%
Lovenox: 8 people, 57.14%
Tylenol W/ Codeine No. 3: 8 people, 57.14%
Rocephin: 8 people, 57.14%

What are other side effects people have besides Intervertebral disc degeneration? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 71.43%
Sinusitis (inflammation of sinus): 10 people, 71.43%
Back Pain: 10 people, 71.43%
Pain In Extremity: 9 people, 64.29%
Atherosclerosis (disorder of the arteries): 9 people, 64.29%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 9 people, 64.29%
Neck Pain: 9 people, 64.29%
Joint Pain: 9 people, 64.29%
Fatigue (feeling of tiredness): 9 people, 64.29%
Fall: 9 people, 64.29%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 8 people, 57.14%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 57.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 14.29%
Stress And Anxiety: 1 person, 7.14%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Breast Cancer: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Naprelan and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naprelan:

Naprelan (731 reports)

Browse all side effects of Naprelan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,310 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,500 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Naprelan) and Naprelan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.