Naprosyn and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Naprosyn (naproxen), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Naproxen, and have Osteoporosis.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Naprosyn. It is created by eHealthMe based on reports of 16,337 people who have side effects when taking Naprosyn from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 967 drugs and 1,094 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

16,337 people reported to have side effects when taking Naprosyn.
Among them, 22 people (0.13%) have Adrenal insufficiency.

Could Naprosyn cause Adrenal insufficiency?

Among these 22 people:

How long have people been on Naprosyn when they have Adrenal insufficiency? *

What is the gender of people who have Adrenal insufficiency when taking Naprosyn? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Adrenal insufficiency when taking Naprosyn? *

What are other drugs people take besides Naprosyn? *

What are other side effects people have besides Adrenal insufficiency? *

Hypotension (abnormally low blood pressure): 18 people, 81.82%
Nausea (feeling of having an urge to vomit): 18 people, 81.82%
Acute Kidney Failure: 17 people, 77.27%
Diarrhea: 17 people, 77.27%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 13 people, 59.09%
Spinal Osteoarthritis (joint cartilage loss in spine): 13 people, 59.09%
Osteopenia (a condition where bone mineral density is lower than normal): 13 people, 59.09%
Pleural Effusion (water on the lungs): 13 people, 59.09%
Weight Decreased: 12 people, 54.55%
Rashes (redness): 12 people, 54.55%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 50.00%
Hiv Infection: 6 people, 27.27%
Bone Density Decreased: 6 people, 27.27%
Bone Loss: 5 people, 22.73%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.55%
Quit Smoking: 1 person, 4.55%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.55%
Neuralgia (pain in one or more nerves): 1 person, 4.55%
Metastases To Bone (cancer spreads to bone): 1 person, 4.55%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naprosyn:

Naprosyn (16,738 reports)

Browse all side effects of Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (967 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,094 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naprosyn) and Naprosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.