Naprosyn and Facet joint syndrome - a phase IV clinical study of FDA data

Summary:

Facet joint syndrome is reported as a side effect among people who take Naprosyn (naproxen), especially for people who are female, 60+ old, also take Ms Contin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Facet joint syndrome when taking Naprosyn. It is created by eHealthMe based on reports of 16,337 people who have side effects when taking Naprosyn from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Facet joint syndrome?

Facet joint syndrome (problem with movement of the facet joints of the spine) is found to be associated with 463 drugs and 119 conditions by eHealthMe. Check the latest studies of Facet joint syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

16,337 people reported to have side effects when taking Naprosyn.
Among them, 11 people (0.07%) have Facet joint syndrome.

Could Naprosyn cause Facet joint syndrome?

Among these 11 people:

What is the gender of people who have Facet joint syndrome when taking Naprosyn? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Facet joint syndrome when taking Naprosyn? *

What are other drugs people take besides Naprosyn? *

Oxycontin: 5 people, 45.45%
Ms Contin: 5 people, 45.45%
Fosamax: 4 people, 36.36%
Lyrica: 4 people, 36.36%
Zometa: 4 people, 36.36%
Vitamin C: 4 people, 36.36%
Folic Acid: 3 people, 27.27%
Aredia: 3 people, 27.27%
Hydrochlorothiazide: 3 people, 27.27%
Hydrocodone Bitartrate And Acetaminophen: 3 people, 27.27%

What are other side effects people have besides Facet joint syndrome? *

Intervertebral Disc Degeneration (spinal disc degeneration): 9 people, 81.82%
Hypoaesthesia (reduced sense of touch or sensation): 8 people, 72.73%
Neuropathy Peripheral (surface nerve damage): 7 people, 63.64%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 6 people, 54.55%
Irritable Bowel Syndrome: 6 people, 54.55%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 54.55%
Neck Pain: 5 people, 45.45%
Femur Fracture: 5 people, 45.45%
Joint Pain: 5 people, 45.45%
Joint Swelling: 5 people, 45.45%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 4 people, 36.36%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 18.18%
Multiple Myeloma (cancer of the plasma cells): 2 people, 18.18%
Metastases To Bone (cancer spreads to bone): 2 people, 18.18%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 2 people, 18.18%
Breast Cancer: 2 people, 18.18%
Sleep Disorder: 1 person, 9.09%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Nervousness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and have Facet joint syndrome?

- Check whether Facet joint syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naprosyn:

Naprosyn (16,738 reports)

Browse all side effects of Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Facet joint syndrome:

Facet joint syndrome (464 drugs)

Browse all the conditions that are associated with Facet joint syndrome:

Facet joint syndrome (119 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naprosyn) and Naprosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.