Narcan and Hepatic enzyme increased - a phase IV clinical study of FDA data

Summary:

Hepatic enzyme increased is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are female, 60+ old, also take Alprazolam, and have Breast cancer female.

The phase IV clinical study analyzes which people have Hepatic enzyme increased when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Hepatic enzyme increased?

Hepatic enzyme increased is found to be associated with 1,885 drugs and 2,016 conditions by eHealthMe. Check the latest studies of Hepatic enzyme increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

3,672 people reported to have side effects when taking Narcan.
Among them, 11 people (0.3%) have Hepatic enzyme increased.

Could Narcan cause Hepatic enzyme increased?

Among these 11 people:

What is the gender of people who have Hepatic enzyme increased when taking Narcan? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Hepatic enzyme increased when taking Narcan? *

What are other drugs people take besides Narcan? *

Hydrocodone Bitartrate And Acetaminophen: 5 people, 45.45%
Alprazolam: 5 people, 45.45%
Albuterol: 4 people, 36.36%
Escitalopram: 4 people, 36.36%
Letrozole: 4 people, 36.36%
Albuterol Sulfate: 4 people, 36.36%
Zolpidem: 4 people, 36.36%
Ibrance: 4 people, 36.36%
Anoro Ellipta: 3 people, 27.27%
Fentanyl: 3 people, 27.27%

What are other side effects people have besides Hepatic enzyme increased? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 54.55%
Constipation: 6 people, 54.55%
Anaemia (lack of blood): 5 people, 45.45%
Fatigue (feeling of tiredness): 5 people, 45.45%
Dry Skin: 4 people, 36.36%
Hypoaesthesia (reduced sense of touch or sensation): 4 people, 36.36%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 36.36%
Nerve Injury: 4 people, 36.36%
Headache (pain in head): 4 people, 36.36%
Hair Loss: 4 people, 36.36%

What are the existing conditions these people have? *

Breast Cancer Female: 4 people, 36.36%
Stress And Anxiety: 2 people, 18.18%
Mycobacterium Abscessus Infection (rapid growing bacterial infection): 2 people, 18.18%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 18.18%
Blood Glucose Decreased: 2 people, 18.18%
Urinary Tract Infection: 1 person, 9.09%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 9.09%
Osteomyelitis (infection of bone): 1 person, 9.09%
Multiple Myeloma (cancer of the plasma cells): 1 person, 9.09%
Breast Cancer: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Hepatic enzyme increased?

- Check whether Hepatic enzyme increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic enzyme increased:

Hepatic enzyme increased (1,885 drugs)

Browse all the conditions that are associated with Hepatic enzyme increased:

Hepatic enzyme increased (2,016 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.