Narcan and Hereditary angioedema - a phase IV clinical study of FDA data

Summary:

Hereditary angioedema is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are male, 50-59 old, also take Incruse Ellipta, and have Immune system disorder.

The phase IV clinical study analyzes which people have Hereditary angioedema when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Hereditary angioedema?

Hereditary angioedema (recurrent episodes of severe swelling) is found to be associated with 471 drugs and 546 conditions by eHealthMe. Check the latest studies of Hereditary angioedema.

On Jul, 12, 2026

3,672 people reported to have side effects when taking Narcan.
Among them, 13 people (0.35%) have Hereditary angioedema.

Could Narcan cause Hereditary angioedema?

Among these 13 people:

What is the gender of people who have Hereditary angioedema when taking Narcan? *

female: 15.38 %
male: 84.62 %

What is the age of people who have Hereditary angioedema when taking Narcan? *

What are other drugs people take besides Narcan? *

What are other side effects people have besides Hereditary angioedema? *

Hepatic Fibrosis (scarring process that represents the liver's response to injury): 9 people, 69.23%
Pulmonary Thrombosis (scarring in the lungs): 8 people, 61.54%
Prostatomegaly (enlargement of the prostate): 7 people, 53.85%
Urinary Tract Infection: 7 people, 53.85%
Fatigue (feeling of tiredness): 6 people, 46.15%
Confusion: 6 people, 46.15%
Pain: 5 people, 38.46%
Nausea (feeling of having an urge to vomit): 5 people, 38.46%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 38.46%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 38.46%

What are the existing conditions these people have? *

Immune System Disorder: 11 people, 84.62%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 7.69%
Pain: 1 person, 7.69%
Itching: 1 person, 7.69%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Hereditary angioedema?

- Check whether Hereditary angioedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hereditary angioedema:

Hereditary angioedema (471 drugs)

Browse all the conditions that are associated with Hereditary angioedema:

Hereditary angioedema (546 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.