Narcan and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Zofran, and have Overdose.

The phase IV clinical study analyzes which people have Hyponatremia when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,941 drugs and 2,277 conditions by eHealthMe. Check the latest studies of Hyponatremia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

3,672 people reported to have side effects when taking Narcan.
Among them, 19 people (0.52%) have Hyponatremia.

Among these 19 people:

How long have people been on Narcan when they have Hyponatremia? *

What is the gender of people who have Hyponatremia when taking Narcan? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Hyponatremia when taking Narcan? *

What are other drugs people take besides Narcan? *

What are other side effects people have besides Hyponatremia? *

Fatigue (feeling of tiredness): 8 people, 42.11%
Weakness: 6 people, 31.58%
Nausea (feeling of having an urge to vomit): 6 people, 31.58%
Dehydration (dryness resulting from the removal of water): 5 people, 26.32%
Gait Disturbance: 5 people, 26.32%
Hypotension (abnormally low blood pressure): 5 people, 26.32%
Cardiac Failure Congestive: 4 people, 21.05%
Haematuria (presence of blood in urine): 4 people, 21.05%
Diarrhea: 4 people, 21.05%
Drowsiness: 4 people, 21.05%

What are the existing conditions these people have? *

Spinal Muscular Atrophy (wasting of spinal muscles): 2 people, 10.53%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 10.53%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 10.53%
Overdose: 2 people, 10.53%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 5.26%
Immunodeficiency Common Variable: 1 person, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%
K-Ras Gene Mutation: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Hyponatremia treatments and more:

Hyponatremia (72,436 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Hyponatremia (1,941 drugs)

Browse all the conditions that are associated with Hyponatremia:

Hyponatremia (2,277 conditions)

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.