Narcan and Renal impairment - a phase IV clinical study of FDA data

Summary:

Renal impairment is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Renal impairment when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Renal impairment?

Renal impairment (severely reduced kidney function) is found to be associated with 2,211 drugs and 2,471 conditions by eHealthMe. Check the latest studies of Renal impairment.

On Aug, 05, 2026

3,672 people reported to have side effects when taking Narcan.
Among them, 27 people (0.74%) have Renal impairment.

Among these 27 people:

How long have people been on Narcan when they have Renal impairment? *

What is the gender of people who have Renal impairment when taking Narcan? *

female: 24 %
male: 76 %

What is the age of people who have Renal impairment when taking Narcan? *

What are other drugs people take besides Narcan? *

What are other side effects people have besides Renal impairment? *

Stress And Anxiety: 19 people, 70.37%
Pain: 19 people, 70.37%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 18 people, 66.67%
Emotional Distress: 18 people, 66.67%
Acute Kidney Failure: 12 people, 44.44%
Bone Density Decreased: 12 people, 44.44%
Chronic Kidney Disease: 9 people, 33.33%
Osteoporosis (bones weak and more likely to break): 9 people, 33.33%
Renal Injury (kidney injury): 7 people, 25.93%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 22.22%

What are the existing conditions these people have? *

Hiv Infection: 18 people, 66.67%
High Blood Cholesterol: 6 people, 22.22%
High Blood Pressure: 6 people, 22.22%
Diabetes: 5 people, 18.52%
Pain: 5 people, 18.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.81%
Depression: 3 people, 11.11%
Hepatitis B: 3 people, 11.11%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 7.41%
Erection Problems: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Renal impairment?

- Check whether Renal impairment is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Renal impairment treatments and more:

Renal impairment (99,633 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Renal impairment:

Renal impairment (2,211 drugs)

Browse all the conditions that are associated with Renal impairment:

Renal impairment (2,471 conditions)

Related publications that referenced our studies

Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.