Narcan and Skin hyperpigmentation - a phase IV clinical study of FDA data

Summary:

Skin hyperpigmentation is reported as a side effect among people who take Narcan (naloxone hydrochloride), especially for people who are male, 30-39 old, also take Dilaudid, and have Nuclear magnetic resonance imaging brain.

The phase IV clinical study analyzes which people have Skin hyperpigmentation when taking Narcan. It is created by eHealthMe based on reports of 3,672 people who have side effects when taking Narcan from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Skin hyperpigmentation?

Skin hyperpigmentation (disorders affect the colour of your skin) is found to be associated with 644 drugs and 812 conditions by eHealthMe. Check the latest studies of Skin hyperpigmentation.

On Jul, 23, 2026

3,672 people reported to have side effects when taking Narcan.
Among them, 11 people (0.3%) have Skin hyperpigmentation.

Could Narcan cause Skin hyperpigmentation?

Among these 11 people:

What is the gender of people who have Skin hyperpigmentation when taking Narcan? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Skin hyperpigmentation when taking Narcan? *

What are other drugs people take besides Narcan? *

What are other side effects people have besides Skin hyperpigmentation? *

Pain: 11 people, 100.00%
Joint Pain: 10 people, 90.91%
Oedema Peripheral (superficial swelling): 10 people, 90.91%
Ecchymosis (a discoloration of the skin resulting from bleeding underneath): 8 people, 72.73%
Rashes (redness): 8 people, 72.73%
Head Injury: 7 people, 63.64%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 7 people, 63.64%
Purpura (purplish discoloration of the skin): 7 people, 63.64%
Pigmentation Disorder (disturbances of human skin colour): 7 people, 63.64%
Skin Plaque (red, scaly patches to appear on the skin): 7 people, 63.64%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 7 people, 63.64%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 27.27%
Pain: 1 person, 9.09%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 9.09%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 1 person, 9.09%
High Blood Cholesterol: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and have Skin hyperpigmentation?

- Check whether Skin hyperpigmentation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Narcan:

Narcan (3,687 reports)

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin hyperpigmentation:

Skin hyperpigmentation (644 drugs)

Browse all the conditions that are associated with Skin hyperpigmentation:

Skin hyperpigmentation (812 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Narcan) and Narcan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.