Nitrofurantoin and Hiatal hernia - a phase IV clinical study of FDA data

Summary:

Hiatal hernia is reported as a side effect among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Prilosec, and have Osteoporosis.

The phase IV clinical study analyzes which people have Hiatal hernia when taking Nitrofurantoin. It is created by eHealthMe based on reports of 4,140 people who have side effects when taking Nitrofurantoin from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,840 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Hiatal hernia?

Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm) is found to be associated with 1,303 drugs and 1,567 conditions by eHealthMe. Check the latest studies of Hiatal hernia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 11, 2026

4,140 people reported to have side effects when taking Nitrofurantoin.
Among them, 57 people (1.38%) have Hiatal hernia.

Could Nitrofurantoin cause Hiatal hernia?

Among these 57 people:

What is the gender of people who have Hiatal hernia when taking Nitrofurantoin? *

female: 96.49 %
male: 3.51 %

What is the age of people who have Hiatal hernia when taking Nitrofurantoin? *

What are other drugs people take besides Nitrofurantoin? *

What are other side effects people have besides Hiatal hernia? *

Stress And Anxiety: 45 people, 78.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 34 people, 59.65%
Fall: 33 people, 57.89%
Head Injury: 29 people, 50.88%
Diarrhea: 29 people, 50.88%
Back Pain: 29 people, 50.88%
Dyspnea (difficult or laboured breathing): 28 people, 49.12%
Pain: 28 people, 49.12%
Constipation: 27 people, 47.37%
Injury: 26 people, 45.61%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 19 people, 33.33%
Insomnia (sleeplessness): 10 people, 17.54%
Ovarian Cancer (cancer of ovary): 10 people, 17.54%
Herpes Virus Infection: 10 people, 17.54%
Nausea (feeling of having an urge to vomit): 10 people, 17.54%
Muscle Aches (muscle pain): 10 people, 17.54%
Breast Cancer: 4 people, 7.02%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 5.26%
Depression: 3 people, 5.26%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrofurantoin and have Hiatal hernia?

- Check whether Hiatal hernia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nitrofurantoin:

Nitrofurantoin (4,840 reports)

Hiatal hernia treatments and more:

Hiatal hernia (28,705 reports)

How severe was Hiatal hernia and when was it recovered:

Hiatal hernia in Nitrofurantoin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Hiatal hernia and drugs with ingredients of nitrofurantoin, macrocrystalline (83 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrofurantoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hiatal hernia:

Hiatal hernia (1,303 drugs)

Browse all the conditions that are associated with Hiatal hernia:

Hiatal hernia (1,567 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Nitrofurantoin) and Nitrofurantoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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