Nitrofurantoin and Hyperkalemia - a phase IV clinical study of FDA data

Summary:

Hyperkalemia is reported as a side effect among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Aspirin, and have Cardiac failure congestive.

The phase IV clinical study analyzes which people have Hyperkalemia when taking Nitrofurantoin. It is created by eHealthMe based on reports of 4,140 people who have side effects when taking Nitrofurantoin from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,837 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Hyperkalemia?

Hyperkalemia (damage to or disease of the kidney) is found to be associated with 1,956 drugs and 2,937 conditions by eHealthMe. Check the latest studies of Hyperkalemia.

On May, 01, 2026

4,140 people reported to have side effects when taking Nitrofurantoin.
Among them, 11 people (0.27%) have Hyperkalemia.

Could Nitrofurantoin cause Hyperkalemia?

Among these 11 people:

What is the gender of people who have Hyperkalemia when taking Nitrofurantoin? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Hyperkalemia when taking Nitrofurantoin? *

What are other drugs people take besides Nitrofurantoin? *

What are other side effects people have besides Hyperkalemia? *

Acute Kidney Failure: 4 people, 36.36%
Confusional State: 2 people, 18.18%
Cardiac Failure Congestive: 2 people, 18.18%
Bradycardia (abnormally slow heart action): 2 people, 18.18%
Blood Sodium Decreased: 2 people, 18.18%
Drug Toxicity: 2 people, 18.18%
International Normalised Ratio Increased: 2 people, 18.18%
Weight Decreased: 1 person, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 9.09%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 1 person, 9.09%

What are the existing conditions these people have? *

Cardiac Failure Congestive: 2 people, 18.18%
Type 2 Diabetes: 1 person, 9.09%
Joint Pain: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Heart Rate Irregular: 1 person, 9.09%
Heart Attack: 1 person, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 9.09%
Diabetes: 1 person, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrofurantoin and have Hyperkalemia?

- Check whether Hyperkalemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nitrofurantoin:

Nitrofurantoin (4,837 reports)

Hyperkalemia treatments and more:

Hyperkalemia (78,084 reports)

How severe was Hyperkalemia and when was it recovered:

Hyperkalemia in Nitrofurantoin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Hyperkalemia and drugs with ingredients of nitrofurantoin, macrocrystalline (29 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrofurantoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkalemia:

Hyperkalemia (1,956 drugs)

Browse all the conditions that are associated with Hyperkalemia:

Hyperkalemia (2,937 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Nitrofurantoin) and Nitrofurantoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.