Nitrofurantoin and Musculoskeletal pain - a phase IV clinical study of FDA data

Summary:

Musculoskeletal pain is reported as a side effect among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Aspirin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Musculoskeletal pain when taking Nitrofurantoin. It is created by eHealthMe based on reports of 4,140 people who have side effects when taking Nitrofurantoin from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,838 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Musculoskeletal pain?

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) is found to be associated with 1,878 drugs and 1,827 conditions by eHealthMe. Check the latest studies of Musculoskeletal pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

4,140 people reported to have side effects when taking Nitrofurantoin.
Among them, 68 people (1.64%) have Musculoskeletal pain.

Could Nitrofurantoin cause Musculoskeletal pain?

Among these 68 people:

How long have people been on Nitrofurantoin when they have Musculoskeletal pain? *

What is the gender of people who have Musculoskeletal pain when taking Nitrofurantoin? *

female: 92.65 %
male: 7.35 %

What is the age of people who have Musculoskeletal pain when taking Nitrofurantoin? *

What are other drugs people take besides Nitrofurantoin? *

What are other side effects people have besides Musculoskeletal pain? *

Pain: 41 people, 60.29%
Back Pain: 40 people, 58.82%
Stress And Anxiety: 35 people, 51.47%
Cough: 34 people, 50.00%
Dyspnea (difficult or laboured breathing): 33 people, 48.53%
Diarrhea: 33 people, 48.53%
Fall: 32 people, 47.06%
Muscle Aches (muscle pain): 30 people, 44.12%
Malaise (a feeling of general discomfort or uneasiness): 30 people, 44.12%
Dry Mouth: 29 people, 42.65%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 31 people, 45.59%
Acne (skin problems that cause pimples): 6 people, 8.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 8.82%
Sleep Disorder: 4 people, 5.88%
Headache (pain in head): 4 people, 5.88%
Premenstrual Syndrome: 4 people, 5.88%
Abnormal Sensation In Eye: 3 people, 4.41%
Birth Control: 3 people, 4.41%
Neoplasm Malignant (cancer tumour): 3 people, 4.41%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrofurantoin and have Musculoskeletal pain?

- Check whether Musculoskeletal pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nitrofurantoin:

Nitrofurantoin (4,838 reports)

Musculoskeletal pain treatments and more:

Musculoskeletal pain (77,217 reports)

How severe was Musculoskeletal pain and when was it recovered:

Musculoskeletal pain in Nitrofurantoin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Musculoskeletal pain and drugs with ingredients of nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrofurantoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,878 drugs)

Browse all the conditions that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,827 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Nitrofurantoin) and Nitrofurantoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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