Norco and Hepatotoxicity aggravated - a phase IV clinical study of FDA data

Summary:

Hepatotoxicity aggravated is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Fever.

The phase IV clinical study analyzes which people have Hepatotoxicity aggravated when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Hepatotoxicity aggravated?

Hepatotoxicity aggravated (serious chemical-driven liver damage) is found to be associated with 926 drugs and 411 conditions by eHealthMe. Check the latest studies of Hepatotoxicity aggravated.

On Jul, 13, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 17 people (0.02%) have Hepatotoxicity aggravated.

Could Norco cause Hepatotoxicity aggravated?

Among these 17 people:

How long have people been on Norco when they have Hepatotoxicity aggravated? *

What is the gender of people who have Hepatotoxicity aggravated when taking Norco? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Hepatotoxicity aggravated when taking Norco? *

What are other drugs people take besides Norco? *

What are other side effects people have besides Hepatotoxicity aggravated? *

Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 29.41%
Pneumonia: 4 people, 23.53%
Blood Bilirubin Increased: 4 people, 23.53%
Pleural Effusion (water on the lungs): 3 people, 17.65%
Fatigue (feeling of tiredness): 3 people, 17.65%
Dyspnea (difficult or laboured breathing): 3 people, 17.65%
Completed Suicide (act of taking one's own life): 2 people, 11.76%
Nausea (feeling of having an urge to vomit): 2 people, 11.76%
Overdose: 2 people, 11.76%
Drug Dependence: 2 people, 11.76%

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 47.06%
Fever: 8 people, 47.06%
Insomnia (sleeplessness): 7 people, 41.18%
Ovarian Cancer (cancer of ovary): 6 people, 35.29%
Cardiac Failure: 5 people, 29.41%
Confusional State: 5 people, 29.41%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 29.41%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 29.41%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 29.41%
Gastrointestinal Anastomotic Leak (breakdown at the site of a post-surgical closure of a stomach and intestine): 5 people, 29.41%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Hepatotoxicity aggravated?

- Check whether Hepatotoxicity aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,063 reports)

Hepatotoxicity aggravated treatments and more:

Hepatotoxicity aggravated (47 reports)

How severe was Hepatotoxicity aggravated and when was it recovered:

Hepatotoxicity aggravated in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Hepatotoxicity aggravated and drugs with ingredients of acetaminophen; hydrocodone bitartrate (179 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatotoxicity aggravated:

Hepatotoxicity aggravated (926 drugs)

Browse all the conditions that are associated with Hepatotoxicity aggravated:

Hepatotoxicity aggravated (411 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.