Norco and Nephrogenic systemic fibrosis - a phase IV clinical study of FDA data

Summary:

Nephrogenic systemic fibrosis is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Optimark, and have Nuclear magnetic resonance imaging brain.

The phase IV clinical study analyzes which people have Nephrogenic systemic fibrosis when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Nephrogenic systemic fibrosis?

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease) is found to be associated with 508 drugs and 673 conditions by eHealthMe. Check the latest studies of Nephrogenic systemic fibrosis.

On Jul, 27, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 55 people (0.08%) have Nephrogenic systemic fibrosis.

Could Norco cause Nephrogenic systemic fibrosis?

Among these 55 people:

How long have people been on Norco when they have Nephrogenic systemic fibrosis? *

What is the gender of people who have Nephrogenic systemic fibrosis when taking Norco? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Nephrogenic systemic fibrosis when taking Norco? *

What are other drugs people take besides Norco? *

What are other side effects people have besides Nephrogenic systemic fibrosis? *

Skin Induration (an abnormally hard spot or area on the skin): 38 people, 69.09%
Skin Hypertrophy (skin cells enlarges): 33 people, 60.00%
Skin Tightness: 33 people, 60.00%
Joint Range Of Motion Decreased (disease of joint movement): 31 people, 56.36%
Oedema Peripheral (superficial swelling): 30 people, 54.55%
Skin Fibrosis (fibrous tissue formation on skin): 28 people, 50.91%
Skin Exfoliation (removal of the oldest dead skin cells): 24 people, 43.64%
Rashes (redness): 24 people, 43.64%
Mobility Decreased (ability to move is reduced): 23 people, 41.82%
Pain Of Skin: 22 people, 40.00%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 26 people, 47.27%
Depression: 14 people, 25.45%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 21.82%
Herpes Zoster: 12 people, 21.82%
Stress And Anxiety: 12 people, 21.82%
High Blood Cholesterol: 12 people, 21.82%
Device Related Infection: 12 people, 21.82%
Itching: 12 people, 21.82%
Nausea (feeling of having an urge to vomit): 12 people, 21.82%
Nuclear Magnetic Resonance Imaging Abdominal: 8 people, 14.55%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Nephrogenic systemic fibrosis?

- Check whether Nephrogenic systemic fibrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,063 reports)

Nephrogenic systemic fibrosis treatments and more:

Nephrogenic systemic fibrosis (6,191 reports)

How severe was Nephrogenic systemic fibrosis and when was it recovered:

Nephrogenic systemic fibrosis in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Nephrogenic systemic fibrosis and drugs with ingredients of acetaminophen; hydrocodone bitartrate (318 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephrogenic systemic fibrosis:

Nephrogenic systemic fibrosis (508 drugs)

Browse all the conditions that are associated with Nephrogenic systemic fibrosis:

Nephrogenic systemic fibrosis (673 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.